Induction of autophagy by spermidine promotes longevity

By T. Eisenberg, H. Knauer, Alexandra Schauer, S. Büttner, C. Ruckenstuhl, D. Carmona‐Gutierrez, J. Ring, Sabrina Schroeder, C. Magnes, Lucia Antonacci and 19 more. Nature Cell Biology, 2009

1,618 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/c821d4bd3998526139a045b0804b341783c5547a

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Citations in the corpus

Replicative and Chronological Aging in Saccharomyces cerevisiae (2012, positive): “In addition, yeast CLS studies were the first to reveal the role of spermidine in longevity (Eisenberg et al., 2009), which also extends life span in worms and flies.”
Epigenetics and aging (2016, background): “Spermidine, a naturally occurring polyamine, directly inhibits HATs, maintaining histone H3 in a hypoacetylated state (222).”
Eaten alive: a history of macroautophagy (2010, background): “Spermidine, a naturally occurring polyamine, also promotes longevity by inducing autophagy, although its lifespan-extending effect has not been investigated clinicall”
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019, background): “In fact, cell death, associated with membrane rupture, was indicative of necrosis (190).”
Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT (2012, background): “PAs play a variety of roles, of which several are related to oxidative stress prevention and suppression of necrosis [31].”
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, background): “2000), a ubiquitous polyamine that has been shown to have beneficial effects on ageing (Eisenberg et al. 2009) and ageassociated memory impairment (Gupta et al.”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “of histone acetyltransferases, leading to significant upregulation of various autophagy-related transcripts.(631) In addition to the ATG genes, transcriptional upregulation of VMP1 (a protein that is involved in autophagy regulation”
Spermidine in health and disease (2018, methodology): “Therefore, the inhibition of EP300 by spermidine causes deacetylation of ATG proteins and increases acetylation of tubulin, thus stimulating autophagic flux (Fig.”
Autophagy and the integrated stress response (2010, positive): “In this context, it is intriguing that p300 acetyltransferase knockdown (Lee and Finkel, 2009), as well as histone acetylase inhibition by spermidine, a natural polyamine, potently induce autophagy (Eisenberg et al., 2009), suggesting that protein acetylation may play a general role in autophagy reg”
Autophagy and aging. (2011, background): “(Insulin/IGF-1 receptor) loss-of-function mutant in C. elegans Enhanced autophagy and life span Abolishment of longevity phenotype in animals with loss-of-function mutations of bec-1 or upon atg-7 or atg-12 RNAi Melendez et al., 2003 Dietary restriction mutant eat-2 (ad1113) in C. elegans.”