Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

By J. Campisi. Cell, 2005

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Kin Selection and the Evolutionary Theory of Aging (2007, background): “Related studies have provided better support for antagonistic pleiotropy than for mutation accumulation as genetic routes to aging (e.g., Campisi 2005, Hughes & Reynolds 2005, Kirkwood & Austad 2000, Leroi et al. 2005, Partridge & Barton 1993, Partridge & Gems 2002a, Rose 1991), with some phenomena…”
Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “While senescence protects against tumor development earlier in life, senescent cells may contribute to aging and agerelated diseases, such as cancer, by compromising tissue renewal and repair (Campisi, 2005).”
The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. (2016, background): “Blocking normal cells in G1 phase can protect them from drugs that target dividing cells (Carvajal et al. 2005; Kranz and Dobbelstein 2006).”
Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Senescent cells can accumulate with age and at sites of age-related pathologies, such as in osteoarthritis (261) and atherosclerosis (47), and can have an impact on the normal physiology of the tissues, causing a progressive functional deterioration.”