A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

By J. Barger, T. Kayo, J. Vann, E. Arias, Jelai Wang, T. Hacker, Ying Wang, D. Raederstorff, J. Morrow, C. Leeuwenburgh and 5 more. PLoS ONE, 2008

618 citations recorded by the source corpus.

Resveratrol in high doses has been shown to extend lifespan in some studies in invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from middle age (14-months) to old age (30-months) either a control diet, a low dose of resveratrol (4.9 mg kg−1 day−1), or a calorie restricted (CR) diet and examined genome-wide transcriptional profiles. We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription. Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/6b1059efc206cf669774b80d40a20cc801ba020a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. D. Sinclair
2. Johan Auwerx
3. L. Guarente
4. C. Cantó
5. Joseph A. Baur
6. Hung-Chun Chang
7. Brian J. North
8. J. Denu

In Geriatrics and Gerontology

1. Johan Auwerx
2. D. Sinclair
3. C. Cantó
4. L. Guarente
5. Joseph A. Baur
6. Hung-Chun Chang
7. Brian J. North
8. J. Denu

In Physiology

1. Johan Auwerx
2. D. Sinclair
3. L. Guarente
4. C. Cantó
5. Joseph A. Baur
6. Hung-Chun Chang
7. Brian J. North
8. Wei Yu

Citations in the corpus

• Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. (2008, background): “…as those occurring during fasting or calorie restriction (Michan and Sinclair, 2007; Rodgers et al., 2005), and it has been suggested that SIRT1 activators act, at least in part, by stimulating physiological pathways activated by low energetic levels (Barger et al., 2008; Pearson et al., 2008).”
• Plant polyphenols as dietary antioxidants in human health and disease (2009, background): “When examined for the mechanism, it activated forkhead box O (FOXO), which regulates the expression of genes that contribute both to longevity and resistance to various stresses and insulin-like growth factorbinding protein 1 (IGFBP-1).(83) There are experimental evidences that resveratrol can exten”
• SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “…metabolic and vascular function, decreased hepatic steatosis, reduced inflammation, greater endurance, and a gene expression pattern resembling calorie restriction (Barger et al., 2008a; Barger et al., 2008b; Baur et al., 2006; Lagouge et al., 2006; Pearson et al., 2008; Ramadori et al., 2009).”
• Resveratrol and health--a comprehensive review of human clinical trials. (2011, background): “Recent data suggest that resveratrol does not extend lifespan in healthy mice or in a model of premature aging [9], but does appear to delay or attenuate many agerelated changes and prevent early mortality in obese animals [10–12].”
• Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan (2008, positive): “In agreement with a concurrent study (Barger et al., 2008), we show that resveratrol induces changes in the transcriptional profiles of key metabolic tissues that closely resemble those induced by DR.”
• SIRT1 and other sirtuins in Metabolism (2013, background): “In addition, SIRT1 activators like resveratrol [44] and newer sirtuin activating compounds (STACs) [45], exert effects that are similar to those of CR as revealed by measures of whole animal physiology [46] or by transcriptional profiling [47].”
• Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-related Hearing Loss under Caloric Restriction (2010, background): “However, recent studies indicate that upregulation of Sirt1 in response to CR is not observed in all tissues examined (Cohen et al., 2004; Barger et al., 2008), and currently, no study has provided conclusive evidence that sirtuins play an essential role in CR-mediated aging retardation in mammals.”