The molecular machinery of autophagy: unanswered questions

By D. Klionsky. Journal of Cell Science, 2005

1,001 citations recorded by the source corpus.

Subfields: Epidemiology, Parasitology, Physiology

View Paper: https://www.semanticscholar.org/paper/57aad4d9bf7e93718aaa0c3478746e6a53373cd2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. D. Klionsky
2. N. Mizushima
3. Beth Levine
4. Guido Kroemer
5. E. White
6. Y. Ohsumi
7. Zhifen Yang
8. I. Slaninová

In Parasitology

1. D. Klionsky
2. N. Mizushima
3. Zhifen Yang
4. Guido Kroemer
5. Y. Ohsumi
6. E. White
7. V. Deretic
8. Congcong He

In Physiology

1. D. Klionsky
2. N. Mizushima
3. Guido Kroemer
4. E. White
5. M. Jäättelä
6. Yongqiang Chen
7. C. Kishi
8. Eisuke Itakura

Citations in the corpus

• Autophagy: from phenomenology to molecular understanding in less than a decade (2007, background): “It is not possible to describe in this Timeline the wealth of information that has been gleaned from analyses of the Atg proteins, and besides, much of this information has been covered in various reviews elsewher”
• Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. (2008, background): “Finally, turnover of a mitochondrion as a whole organelle is mediated by mitochondrial autophagy or mitophagy [7,8].”
• Atg32 is a mitochondrial protein that confers selectivity during mitophagy (2009, background): “Selective autophagy includes the cytoplasm to vacuole targeting (Cvt) pathway (Klionsky and Emr, 2000; Yorimitsu and Klionsky, 2005) and pexophagy (Dunn et al., 2005), which have the Cvt complex (aminopeptidase I (Ape1), along with receptor and adaptor proteins) and peroxisomes as specific cargo,…”
• Principles and Current Strategies for Targeting Autophagy for Cancer Treatment (2011, background): “They include distinct steps for AV production and turnover, including (1) initiation, (2) nucleation of, and (3) maturation of AVs, and (4) fusion and degradation of AV contents in lysosomes (Fig.”
• Mammalian autophagy: core molecular machinery and signaling regulation (2009, background): “Autophagy, literally meaning “self-eating”, embraces three major intracellular pathways in eukaryotic cells, macroautophagy, microautophagy and chaperone-mediated autophagy (CMA), which share a common destiny of lysosomal degradation, but are mechanistically different from each other [1,2].”
• Biological functions of antioxidants in plant transformation (2008, background): “Autophagy is a process in which cytosol and organelles are sequestered within doublemembrane vesicles that deliver the contents to the lysosome/vacuole for degradation and recycling of the resulting macromolecules (Klionsky 2005).”
• Microautophagy: lesser-known self-eating (2011, neutral): “In macroautophagy, the double- or multi-membrane-delimited autophagosome sequesters the cytoplasm in a large and non-specific way, and then fuses with the lysosome for degradation [7].”
• Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking (2008, background): “dtd" [ ]> Autophagy is a tightly regulated membrane rearrangement process that ensures lysosome-dependent bulk degradation of cytosolic proteins or organelles, and is highly conserved in eukaryotic cells, as seen with the endocytic pathwa”
• The regulation of autophagy – unanswered questions (2011, background): “According to the different pathways by which cargo is delivered to the lysosome or vacuole, autophagy is divided into three main types: chaperone-mediated autophagy (CMA), microautophagy and macroautophagy (Klionsky, 2005).”
• Autophagosome formation: core machinery and adaptations (2007, background): “Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J. Biol. Chem. 277, 18619–18625 (2002). 66. Mizushima, N., Noda, T. & Ohsumi, Y. Apg16p is required for the function of the Apg12pApg5p conjugate in the”
• An Overview of the Molecular Mechanism of Autophagy (2009, background): “4 of Yorimitsu and Klionsky (2005b) Curr Top Microbiol Immunol.”
• Role of autophagy in cancer (2007, background): “The autophagy-regulated or Atg proteins are required for the activation of autophagy, the formation of autophagosomes, the sequestration of intracellular constituents, and the targeting and fusion of autophagosomes to lysosomes where the contents are degraded and recycle”