Insulin-like growth factors and neoplasia

By Michael Pollak, E. Schernhammer, S. Hankinson. Nature Reviews. Cancer, 2004

1,533 citations recorded by the source corpus.

Subfields: Cancer Research, Endocrinology, Diabetes and Metabolism, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cf7b0744450e4d6286bdc3552960a5d68e957d8e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. George Davey Smith
2. Nahum Sonenberg
3. You Han Bae
4. Michael Pollak

In Endocrinology, Diabetes and Metabolism

1. George Davey Smith
2. Michael Pollak

In Molecular Biology

1. Michael Pollak
2. Funda Meric-Bernstam
3. George Davey Smith
4. Nahum Sonenberg
5. You Han Bae
6. V. Longo
7. David M. Sabatini
8. M. Karin

Citations in the corpus

• Recent progress in tumor pH targeting nanotechnology. (2008, background): “In clinical setting, additional tumor microenvironmental factors such as epidermal growth factor, fibroblast growth factor, insulin-like growth factor, and extracellular matrix components are strongly associated with survival mechanisms of cancer cells under cytotoxic drug treatment [37-40].”
• Growth Hormone Receptor Deficiency is Associated With a Major Reduction in Pro-aging Signaling, Cancer and Diabetes in Humans (2011, positive): “This link is supported by some population studies but not others which instead indicate only a modest association between high IGF-I concentrations and increased risk of certain cancers (30, 31).”
• A life course approach to chronic disease epidemiology. (2005, background): “IGF-1 and its binding proteins are important mediators between growth hormone and growth and have been linked to prostate, colorectal, and premenopausal breast cancer (155, 163).”
• Insulin and insulin-like growth factor signalling in neoplasia (2008, background): “We and others have previously presented overviews of the molecular physiology and structural biology involved in insulin and IGF signal transductio”
• Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population (2014, neutral): “This is in agreement with previous studies associating IGF-1 levels to various types of cancer (Giovannucci et al., 2003; Guevara-Aguirre et al., 2011; Pollak et al., 2004).”
• Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. (2009, background): “Insulin can promote tumorigenesis directly by affecting epithelial tissues or indirectly by affecting the levels of other modulators, such as insulin-like growth factors, sex hormones, and adipokines.(3,13-16) Metformin is a widely prescribed oral medication used as firstline therapy for type 2 diab”
• Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. (2006, background): “13) that, at the level of whole-organism physiology, this protection is mediated at least in part by the suppressive effect of dietary restriction on the circulating level of IGF-I, which influences cancer risk (14).”
• Obesity and Cancer: The Role of Dysfunctional Adipose Tissue (2009, background): “IGF-1 can inhibit apoptosis and stimulate cell proliferation through several downstream signaling networks, including the phosphatidylinositol 3-kinase (PI3-K) -AKT system and the Ras/Raf/ mitogen-activated-protein-kinase (MAPK) systems, respectively (49).”