A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan
By Sebastian Brandhorst, I. Choi, Min Wei, Chia-Wei Cheng, S. Sedrakyan, Gerardo Navarrete, L. Dubeau, Li-peng Yap, R. Park, M. Vinciguerra and 16 more. Cell Metabolism, 2015
768 citations recorded by the source corpus.
Summary Prolonged fasting (PF) promotes stress resistance but its effects on longevity are poorly understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan independently of established pro-longevity genes. In mice, four days of a diet that mimics fasting (FMD), developed to minimize the burden of PF, decreased the size of multiple organs/systems; an effect followed upon re-feeding by an elevated number of progenitor and stem cells and regeneration. Bi-monthly FMD cycles started at middle age extended longevity, lowered visceral fat, reduced cancer incidence and skin lesions, rejuvenated the immune system, and retarded bone mineral density loss. In old mice, FMD cycles promoted hippocampal neurogenesis, lowered IGF-1 levels and PKA activity, elevated NeuroD1, and improved cognitive performance. In a pilot clinical trial, three FMD cycles decreased risk factors/biomarkers for aging, diabetes, cardiovascular disease and cancer without major adverse effects, providing support for the use of FMDs to promote healthspan.
Subfields: Aging, Physiology
View Paper: https://www.semanticscholar.org/paper/ab2465e23dfd4b163ac9374347e7fce276aa1288
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Citations in the corpus
- Metabolic Control of Longevity. (2016, background): “When administered to patients (for 5 days per month, over 3 months), an FMD covering 44% ± 10% of the average caloric intake and containing 10% of proteins reduced baseline glucose, circulating IGF1 and C-reactive protein (Brandhorst et al., 2015).”
- Impact of intermittent fasting on health and disease processes (2016, positive): “Considering the recent development of relatively high calorie MDs tested in both mice and humans (Brandhorst et al., 2015), nd the ability of the combination of PF or FMDs with chemotherpy to have very strong effects including cancer-free survival in ultiple murine cancer models, it will be importan”
- Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting (2017, background): “Compared with mice fed ad libitum, mice on the 4:3 IF diet also exhibit reductions in plasma glucose levels and elevations of ketone levels, which are most pronounced at the end of the fasting period (66).”
- Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. (2018, positive): “Data from these trials suggest that IF has similar benefits in humans: IF can reduce body weight or body fat, improve insulin sensitivity, reduce glucose and/or insulin levels, lower blood pressure, improve lipid profiles, and reduce markers of inflammation and oxidative stress (Bhutani et al., 2013”
- MYC, Metabolism, and Cancer. (2015, background): “Hence, throughout evolution, organisms incorporate adaptive mechanisms in response to periods of feast and long periods of famine (81).”