Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice

By Baohua Zhou, M. Comeau, T. D. Smedt, H. D. Liggitt, Martin E. Dahl, D. Lewis, Dora Gyarmati, T. Aye, D. Campbell, Steven F. Ziegler. Nature Immunology, 2005

845 citations recorded by the source corpus.

Subfields: Dermatology, Immunology and Allergy, Physiology

View Paper: https://www.semanticscholar.org/paper/6d3730b041811db3e84ef65c99c0e03c623e01a9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology and Allergy

1. R. Medzhitov
2. Caroline L. Sokol

In Physiology

1. H. Hammad
2. B. Lambrecht
3. R. Medzhitov
4. TA Wynn
5. Caroline L. Sokol

Citations in the corpus

• Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia (2009, background): “TSLP-CRLF2 signaling has important roles in T-cell and dendritic cell development, inflammation and allergic diseas”
• Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction (2009, background): “TSLP is an initiator of allergic airway inflammation in mic”
• How are TH2-type immune responses initiated and amplified? (2010, background): “Functions of TSLP: initiation, amplification or both? TSLP is produced by epithelial cells, mast cells and basophil”
• Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma (2008, background): “By contrast, Tlspr −/− mice fail to develop an antigen-specific T H 2-cell inflammatory response in the airways unless they are supplemented with wild-type CD4 + T cell”
• New insights into the regulation of T cells by γc family cytokines (2009, neutral): “Blocking TSLP with a soluble TSLPR-specific antibody has been shown to protect against the development of pulmonary allergic inflammation in a mouse mode”
• House dust mite allergen induces asthma via TLR4 triggering of airway structural cells (2009, methodology): “, we evaluated the production of cytokines known to promote eosinophilic inflammatio”
• Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation (2014, background): “The stimulation of DCs (Zhou et al., 2005) and basophils (Siracusa et al.”
• The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. (2012, neutral): “Together with the notion that TSLP polymorphisms are associated with atopy (reviewed in Ziegler and Artis, 2010) and that TSLP receptor-deficient mice are resistant to ovalbumininduced asthma (Zhou et al., 2005), this suggests a role for TSLP in the pathogenesis of these diseases.”
• A mechanism for the initiation of allergen-induced T helper type 2 responses (2008, background): “In the setting of chronic allergic inflammation, TSLP production in peripheral tissues has been associated with effector T H 2 response”
• Integrating mechanisms of pulmonary fibrosis (2011, background): “…both T cells and epithelial cells, also represent potential targets for antifibrotic therapy, as each of these cytokines has been reported to play a major role in the induction and/or amplification of type 2 immunity (Fort et al., 2001; Schmitz et al., 2005; Zhou et al., 2005; Pesce et al., 2006).”
• Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells (2007, background): “DCs are crucial for asthmatic inflammation because they recruit Th2 lymphocytes to the airway wall and trigger local Th2 effector cytokine productio”