Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma

By H. Hammad, B. Lambrecht. Nature reviews. Immunology, 2008

688 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/fa0f7227f3465255407a501cbbb85120ed106355

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. H. Hammad
2. B. Lambrecht
3. S. Galli
4. M. Tsai
5. O. Joffre
6. M. Nolte
7. R. Spörri
8. C. Reis e Sousa

In Physiology

1. S. Galli
2. H. Hammad
3. B. Lambrecht
4. M. Tsai
5. S. Holgate
6. Riccardo Polosa

Citations in the corpus

• Rhinitis and sinusitis. (2010, neutral): “For example, protease activities of several common aeroallergens can facilitate allergen access to antigen-presenting cells by cleaving tight junctions in the airway epithelium and activation of protease-activated receptors on epithelial cells.(8) Activated epithelial cells then produce cytokines, c”
• The development of allergic inflammation (2008, background): “Another important factor is the pattern of contact of the immune system with allergens: for example, the amount, frequency and/or route of allergen exposure; and the type (myeloid and/or plasmacytoid) and phenotypic characteristics of the dendritic-cell subpopulations that participate in the respons”
• Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “Other soluble factors, such as granulocyte–macrophage colony-stimulating factor, IL-1b, IL-33, osteopontin, and IL-25 can also be produced by airway epithelial cells and thereby indirectly act on DCs (42).”
• Treatment strategies for allergy and asthma (2008, background): “The crucial role played by dendritic cells (DCs) acting as professional APCs in this sensitization process is reviewed by Hamida Hammad and Bart Lambrecht in this issu”
• Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen (2010, background): “We and others have recently shown that TLR4 triggering and C-type lectin triggering on epithelial cells is crucial for mounting an innate cytokine response to HDM, consisting of production of GM-CSF, TSLP, IL-25, and IL-33 and production of chemokines like CCL2 and CCL20 (Hammad et al., 2009; Nathan”