Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation
By T. Halim, Catherine A. Steer, Laura Mathä, Matthew J. Gold, Itziar Martinez-Gonzalez, K. McNagny, Andrew N. J. McKenzie, F. Takei. Immunity, 2014
892 citations recorded by the source corpus.
Summary Naive CD4+ T cell differentiation into distinct subsets of T helper (Th) cells is a pivotal process in the initiation of the adaptive immune response. Allergens predominantly stimulate Th2 cells, causing allergic inflammation. However, why allergens induce Th2 cell differentiation is not well understood. Here we show that group 2 innate lymphoid cells (ILC2s) are required to mount a robust Th2 cell response to the protease-allergen papain. Intranasal administration of papain stimulated ILC2s and Th2 cells, causing allergic lung inflammation and elevated immunoglobulin E titers. This process was severely impaired in ILC2-deficient mice. Whereas interleukin-4 (IL-4) was dispensable for papain-induced Th2 cell differentiation, ILC2-derived IL-13 was critical as it promoted migration of activated lung dendritic cells into the draining lymph node where they primed naive T cells to differentiate into Th2 cells. Papain-induced ILC2 activation and Th2 cell differentiation was IL-33-dependent, suggesting a common pathway in the initiation of Th2 cell responses to allergen.
Subfields: Immunology, Surgery
View Paper: https://www.semanticscholar.org/paper/59ad96062f9bcfbea395be8afbc5f9a43214520d
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Citations in the corpus
- The chemokine system in innate immunity. (2015, background): “Although all NK cells express CXCR1, CXCR3, and CXCR4, CD56high NK cells also express CCR7, allowing for homeostatic migration to the LNs (Maghazachi 2010).”
- MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion (2014, background): “The impairment of T cell responses suggested that in addition to conventional T cell priming by DCs, which is essential for efficient Th2 generation (Hammad et al., 2010; PhythianAdams et al., 2010), ILC2s might also play a previously unanticipated role in the initiation of protective type-2…”
- Innate Lymphoid Cells: a new paradigm in immunology (2015, background): “Likewise, the production of IL-13 by ILC2s leads to the activation of DCs, their migration into the draining lymph nodes and the differentiation of TH2 cells (89).”