Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

By M. Idzko, H. Hammad, M. Nimwegen, M. Kool, M. Willart, Femke Muskens, Henk C. Hoogsteden, W. Luttmann, D. Ferrari, F. Virgilio and 2 more. Nature Medicine, 2007

643 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/c21a438081b6c817bc6f6fa89bffc5a59e2e7ff5

How researchers see this paper

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In Physiology

1. H. Hammad
2. B. Lambrecht
3. J. Tschopp
4. Haitao Wen
5. J. Ting

Citations in the corpus

• Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma (2008, background): “Administration of stable ATP analogues induced a break in inhalation tolerance by inducing the activation and migration of DC”
• The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases (2011, background): “A similar scenario is seen in allergic or asthmatic inflammation (41), where selective inhibition of the P2X7 receptor or inhibition of uric acid formation in mice decreased the inflammatory pathology seen in allergic models (40).”
• Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome (2008, background): “The data are most consistent with the notion that NALP3-dependent IL-1 production by DCs skews the adaptive cellular immune response toward a Th2 type of response, as recently proposed (25).”
• The inflammasomes: guardians of the body. (2009, background): “Although extracellular ATP has been shown to be involved in inflammatory conditions, as in asthmatic airway inflammation (110), the physiological significance of extracellular ATP-mediated NALP3 inflammasome activation still remains to be demonstrated in vivo.”