A mechanism for the initiation of allergen-induced T helper type 2 responses

By Caroline L. Sokol, G. Barton, A. Farr, R. Medzhitov. Nature Immunology, 2008

1,000 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Physiology

View Paper: https://www.semanticscholar.org/paper/f5d473e76fb48877ab5389044c9fe3a2c54b5a4f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology and Allergy

1. J. Ravetch
2. R. Medzhitov
3. S. Nakae

In Physiology

1. H. Hammad
2. B. Lambrecht
3. R. Medzhitov
4. S. Nakae

Citations in the corpus

• Inflammatory signals in dendritic cell activation and the induction of adaptive immunity (2009, background): “These data additionally imply the existence of a Th2-inducing signal 3, for example a Notch ligand (81, 82) and ⁄ or soluble mediators like IL-4 and TSLP (83).”
• IL-33 is a crucial amplifier of innate rather than acquired immunity (2010, background): “2B), although papain-induced airway inflammation has been considered to be mediated by Th2 cells when mice were first sensitized with papain (18).”
• Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen (2010, background): “During the course of our studies, we discovered that depleting antibodies to FcR1 that were used for depleting basophils (Denzel et al., 2008; Sokol et al., 2008, 2009; Perrigoue et al., 2009; Yoshimoto et al., 2009) also depleted a subset of antigen-presenting inflammatory DCs, whereas the…”
• Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway (2011, background): “To determine whether basophils were involved in this response, we selectively depleted these cells in vivo”
• How are TH2-type immune responses initiated and amplified? (2010, background): “In vitro treatment of basophils with the cysteine protease papain results in their production of IL-4 and TSL”
• House dust mite allergen induces asthma via TLR4 triggering of airway structural cells (2009, background): “TSLP is produced by epithelial cells, mast cells and basophils and activates DCs and mast cell”
• Origin and physiological roles of inflammation (2008, background): “Similarly, the proteolytic activity of proteases produced by helminths is sensed by basophils by an unknown senso”
• The diagnosis and management of acute and chronic urticaria: 2014 update. (2014, background): “This might also suggest a role for serum proteases in patients with acute urticaria.(29) Summary Statement 5: Acute urticaria and angioedema are more frequently associated with identifiable conditions.”