New insights into the regulation of T cells by γc family cytokines

By Yrina Rochman, R. Spolski, W. Leonard. Nature reviews. Immunology, 2009

953 citations recorded by the source corpus.

Common cytokine receptor γ-chain (γc) family cytokines have crucial roles in the development, proliferation, survival and differentiation of multiple cell lineages of both the innate and adaptive immune systems. In this Review, we focus on our current understanding of the distinct and overlapping effects of interleukin-2 (IL-2), IL-7, IL-9, IL-15 and IL-21, as well as the IL-7-related cytokine thymic stromal lymphopoietin (TSLP), on the survival and proliferation of conventional αβ T cells, γδ T cells and regulatory T cells. This knowledge potentially allows for the therapeutic manipulation of immune responses for the treatment of cancer, autoimmunity, allergic diseases and immunodeficiency, as well as for vaccine development.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/2026cf454218d7f5e0e9a682e4653be2834b4326

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In Immunology

1. Jian-Xin Lin
2. W. Liao
3. Jinfang Zhu
4. W. E. Paul
5. W. Leonard
6. K. Margolin
7. Sylvia M. Lee
8. Di Yu

Citations in the corpus

• Cytokines in Cancer Immunotherapy (2011, methodology): “The Type I cytokine receptors, which include receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21, share a common signaling subunit, the common chain ( c), that complexes with a cytokine specific moiety to initiate intracellular signals through the coordinated activity of Janus kinases (JAK) 1 and ”
• Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, neutral): “…et al., 1994), and IL-2Rg (CD132) (Takeshita et al., 1992) was renamed as the common cytokine receptor g chain, gc (Leonard et al., 1995; Noguchi et al., 1993a; Russell et al., 1993); gc is now known to be shared by IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 (Leonard, 2001; Rochman et al., 2009).”
• IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses (2010, background): “The function of common chain cytokines is modified by the context in which they are delivered (Rochman et al., 2009), and there is evidence suggesting that the magnitude of Tfh cell populations is influenced by the types of antigen, adjuvant, and avidity of TCR (Ansel et al., 1999; Malherbe et…”
• IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation (2011, background): “IL-2 itself primarily acts on lymphoid populations, including T [10], B [11], and NK [12] cells, but in addition, it can exert functional effects on other hematopoietic lineages, including, for example, neutrophils [13] (reviewed in [2]) (Table 1).”
• Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, neutral): “…antigendriven immune responses, and the suppression of these and unwanted autoreactive responses are highly dependent and regulated by cytokines (including interleukin-2 [IL-2], IL-4, IL-7, IL-9, IL-15, and IL-21) that utilize receptors in the common g-chain (gc) family (Rochman et al., 2009).”
• How are TH2-type immune responses initiated and amplified? (2010, background): “The production of many other cytokines, including IL-2 (Ref”