Mechanisms of suppression by suppressor T cells

By H. von Boehmer. Nature Immunology, 2005

1,003 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b4da6ec59bcd1872445290ad45eafe2959a6bfe1

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Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. (2007, background): “…as noted above, several different mechanisms are potentially rele- vant for Treg cell-mediated immune suppression, includ- ing cytokine-mediated (e.g., TGF-b, IL-10) as well as cell-surface molecule-dependent inhibition of T cells and APCs (e.g., GITR and CTLA4) (von Boehmer, 2005; Zou, 2006).”
Molecular mechanism and function of CD40/CD40L engagement in the immune system (2009, background): “However, regulatory T cells may also mediate suppression by eliciting IDO from DCs (171).”
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease (2006, background): “They potently suppress the activation, proliferation, and/or effector functions of other CD4 and CD8 T cells, and possibly natural killer (NK) cells, NKT cells, B cells, and dendritic cells (DCs); although, as yet the molecular basis of their suppressive activity has not been fully elucidated (16).”
Regulatory T cells and immune tolerance. (2008, background): “…also suppress effector activities of differentiated CD4 + and CD8 + T cells and the function of natural killer cells, natural killer T cells, B cells, macrophages, osteoclasts, and dendritic cells (reviewed in von Boehmer, 2005; Shevach, 2006; Miyara and Sakaguchi, 2007; Tang and Bluestone, 2008).”
Mechanisms of immune evasion by tumors. (2006, background): “Aside from the burgeoning families of coinhibitory and costimulatory molecules, a great deal of interest in both tumor immunity and infectious immunity has focused on regulatory T cells (Treg) (von Boehmer, 2005).”
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice (2007, background): “Subsequently, it has been proposed that 'nonregulatory' Foxp3 − T cells specific to self or environmental antigens can also upregulate Foxp3 and acquire regulatory properties in the peripher”
The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 (2006, background): “We found that mature peripheral CD4 CD25 T cells, that are relatively resistant to CD3 down-regulation by LT-K, can indeed convert to a CD4 CD25 Treg phenotype through a process requiring GCN2 and leading to a gradual decrease in IL-2 production and up-regulation of IL-10 and TGF- .”