Genomic imprinting: parental influence on the genome

By Wolf Reik, Jörn Walter. Nature reviews genetics, 2001

2,327 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/6be2b5196e5069f3063b8b494bf542d1d577ac7c

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Citations in the corpus

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. (2004, background): “Thus, the noncoding transcripts share important functional character- 2001) and plants (Hamilton and Baulcombe, 1999), gene imprinting (Reik and Walter, 2001; Sleutels and Barlow,istics of protein-coding genes, and indeed the two sets of transcripts cannot be distinguished by the functional 2002),…”
Chromatin modification and epigenetic reprogramming in mammalian development (2002, background): “These differences originate from the differential modification of the genome (or genomic imprinting) in the male and female gamete”
DNA methylation and human disease (2005, background): “Whereas DMRs can be reprogrammed during development, differential methylation in ICRs is generally established in germ cells and maintained throughout developmen”
Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b (2003, background): “De novo methylation also occurs during gametogenesis in both male and female germ cells and is believed to play a critical role in the establishment of genomic imprinting, an epigenetic process that results in differential modification of paternal and maternal alleles during gametogenesis and monoal”
The role of RNA interference in heterochromatic silencing (2004, background): “Parent-of-origin-specific imprints imposed in the germ line are ‘remembered’ after fertilization, and are associated with changes in DNA and histone H3 methyl-atio”
PGC7/Stella protects against DNA demethylation in early embryogenesis (2007, background): “All these genes are reportedly methylated to some extent in the maternal genome after fertilizatio”
DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation. (2006, background): “Imprinted genes reside in chromosomal clusters and are regulated by differentially methylated imprinting control regions (ICRs) (Reik and Walter, 2001).”
Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse (2003, background): “E-mail wolf.reik@bbsrc.ac.uk Contract grant sponsor: BBSRC and MRC. DOI: 10.1002/gene.10168 © 2003 Wiley-Liss, Inc. genesis 35:88–93 (2003) (Reik and Walter, 2001).”
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002, background): “In addition to their role in protein synthesis (ribosomal and transfer RNAs), non-coding RNAs have been implicated in control processes such as genomic imprintin”
DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in arabidopsis. (2002, background): “Thus, only the maternal MEA allele and not the paternal MEA allele, printing in mammals reflects modifications in DNA methylation (Reik and Walter, 2001) and the sporadic develis exposed to DME activity.”
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. (2009, result): “This heterogeneity is less likely to play a role for the affected imprinted loci IGF2 (20), GNASAS and MEG3, since methylation is generally celltype independent for imprinted loci (32) and the observed differences for non-imprinted loci between exposed individuals and controls were similar.”