Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse

By Natasha Lane, W. Dean, S. Erhardt, P. Hájková, A. Surani, Jörn Walter, Wolf Reik. Genesis, 2003

662 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ee59d2c73f54ae208905bf7359ededf1f3160ab7

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In Molecular Biology

Citations in the corpus

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. (2008, positive): “During spermatogenesis, the DNA methylation status of the regulatory regions in retrotransposons, such as IAP (intracisternal A particle) and Line-1 (long interspersed nuclear elements), which belong to the long terminal repeat (LTR) and non-LTR retrotransposon families, respectively, changes dynami”
Stability and flexibility of epigenetic gene regulation in mammalian development (2007, background): “Not all genomic methylation is lost, however, at these stages; some transposons such as IAPs remain fairly highly methylate”
Epigenetic events in mammalian germ-cell development: reprogramming and beyond (2008, background): “For example, DNA methylation of the intra-cisternal A particle (IAP) retrotransposon family is only partially reprogramme”
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. (2008, methodology): “and PCR conditions for amplification of LINE1 and IAP sequences are previously described ( Lane et al., 2003 ).”
Inherited epigenetic variation — revisiting soft inheritance (2006, background): “Even in mammals the erasure of 5mC marks is not absolut”
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis (2005, background): “During murine preimplantation development methylation levels decrease with some notable exceptions including imprinted genes and IAP elements (3,15).”
Epigenetics as a unifying principle in the aetiology of complex traits and diseases (2010, background): “And, in mammals, methylated DNA marks are not always completely erased during gametogenesi”
Understanding transgenerational epigenetic inheritance via the gametes in mammals (2012, background): “But some classes of retrotransposons — in particular, intracisternal A-type particles (IAPs) — have been found to remain methylated in mature gametes and early pre-implantation embryos in mic”
The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells (2012, background): “First, IAPs are the class of sequences most resistant to demethylation, as previously observed (Lane et al., 2003; Guibert et al., 2012), consistent with IAPs being the evolutionarily most recently acquired transposon family in the mouse genome, which is still potentially very active and hence…”
Targets and dynamics of promoter DNA methylation during early mouse development (2010, positive): “It has also been shown that intracisternal A-particles (IAPs) partially resist demethylation in preimplantation embryo”
Epigenetics: Definition, Mechanisms and Clinical Perspective (2009, background): “Evidence suggests that many IAPs fail to undergo epigenetic reprogramming during germ cell development.(83) The high incidence of IAPs in mammalian genomes has consequently led to the belief that this type of transgenerational inheritance may be more prevalent than initially conceived.”