Chromatin modification and epigenetic reprogramming in mammalian development

By E. Li. Nature reviews genetics, 2002

1,986 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/014bb1d12e0637dd1c92d34a047054de293f584a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Wolf Reik
2. E. Li
3. Michael Joseph Meaney
4. A. Bird
5. Keith D. Robertson
6. W. Dean
7. Fátima Santos
8. S. Andersen

In Molecular Biology

1. Yi Zhang
2. Wolf Reik
3. A. Bird
4. Michael Joseph Meaney
5. E. Li
6. Keith D. Robertson
7. Hao Wu
8. W. Dean

Citations in the corpus

• DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “5.(13,16) Possessing homology to DNMT3A and DNMT3B, DNMT3L assists the de novo methyltransferases by increasing their ability to bind to the methyl group donor, S-adenosyl-Lmethionine (SAM), and stimulating their activity in vivo,(17) although DNMT3L has no catalytic activity itself.”
• A meiotic time-course for Arabidopsis thaliana (2003, background): “Many of these events are known to occur during meiosis or closely associated stages of gametogenesis in mammals, although the precise timings of these events have not been defined (Li 2002).”
• Trajectories of brain development: point of vulnerability or window of opportunity? (2003, background): “those that have a heritable influence on chromosome or gene function without changes in gene structure [136], occurs at various levels of structure and function.”
• Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b (2003, background): “DNA methylation is essential for mammalian development and plays crucial roles in a variety of biological processes, such as genomic imprinting and X chromosome inactivation (26).”
• Dynamic changes in the human methylome during differentiation. (2010, background): “course of development (Li 2002), and result in transcriptional repression of the adjacent genes.”
• Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. (2005, background): “During development, a wave of de novo methylation is critical for proper differentiation (for review, see Li 2002) and, as further discussed below, we present evidence that related processes are impaired in DCR ⌬/⌬ cells.”
• Maternal care as a model for experience-dependent chromatin plasticity? (2005, background): “A region of methylated DNA attracts different members of a family of methylated DNA-binding proteins, such as MeCP2, which recruit HDACs [43,44] and histone methyltransferases [44] to methylated genes [ 32 ,44], blocking histone acetylation and inactivating chromatin.”
• Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome (2005, background): “DNA methylation is essential for embryonic development in the mouse and has a role in genomic imprintin”
• Early detection: The power and the promise of DNA methylation markers (2003, neutral): “Dense methylation of promoter regions is associated with a compacted chromatin structure, and accompanying transcriptional silencing of the affiliated gen”
• Child health, developmental plasticity, and epigenetic programming. (2011, background): “Only a few environmental influences have been shown to cause DNA sequence changes that could explain altered gene expression or increases in disease frequency in a particular region (414).”