PGC7/Stella protects against DNA demethylation in early embryogenesis

By Toshinobu Nakamura, Yoshikazu Arai, H. Umehara, M. Masuhara, Tohru Kimura, H. Taniguchi, T. Sekimoto, M. Ikawa, Y. Yoneda, M. Okabe and 3 more. Nature Cell Biology, 2007

594 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/59807da0009b1909f84c52327751d984314bc1c9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

In Pediatrics, Perinatology and Child Health

Citations in the corpus

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine (2011, methodology): “As a control, we measured the expression of the Stella/ Dppa3 transcript encoding a protein that protects the maternal genome from active DNA demethylation (42).”
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (2014, background): “Although STELLA appeared to localize to both pronuclei in the zygote, its binding to the paternal genome is weak (Nakamura et al. 2012).”
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, unknown): “In the absence of Stella, TET3 is localized to both paternal and maternal genomes (Nakamura et al., 2012; Wossidlo et al., 2011), and the maternal genome also undergoes 5mC oxidation (Nakamura et al., 2007; Nakamura et al., 2012).”
Genomic imprinting: the emergence of an epigenetic paradigm (2011, background): “75 ) and developmental pluripotency-associated protein 3 (DPPA3; also known as PGC7 or Stella”
Interpreting thelanguage of histone and DNA modifications (2014, background): “Indeed, recognition of H3K9me2 by the maternal factor PGC7 is necessary to protect maternal 5mC from TET3-mediated oxidative demethylation [216,217] (Fig.”
5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. (2011, background): “PGC7 protects the maternal genome against hydroxylation The maintenance of 5mC in the maternal pronucleus was shown to depend on the 'demethylation' protecting factor PGC7/Dppa3/Stell”
Epigenetics: Definition, Mechanisms and Clinical Perspective (2009, background): “Stella is among a group of proteins that may play an important role in the suppression of epigenetic reprogramming of these specific sequences.(81) The failure to erase epigenetic marks during primordial germ cell development or subsequent early embryogenesis is at the origin of transgenerational in”
DNA Demethylation Dynamics (2011, background): “Studies report that, following fertilization, the paternal pronuclei undergo an extensive loss of 5mC (Oswald et al., 2000), whereas the maternal pronuclei are resistant to this loss due to the presence of the protein Stella (Nakamura et al., 2007).”
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “…not recognize 5hmC (Valinluck et al. 2004; Jin et al. 2010), thereby providing a potential means to reverse the gene silencing effect mediated by promoter DNA methylation-dependent recruitment of MBD proteins and their associated corepressor protein complexes (Nan et al. 1998; Feng and Zhang 2001).”
A maternal-zygotic effect gene Zfp57 maintains both maternal and paternal imprints (2008, background): “Oocyte-derived PGC7/Stella was shown to confer partial protection from demethylation at one class of repetitive sequence and at some imprinted domains (Nakamura et al., 2007).”
Active DNA Demethylation Mediated by DNA Glycosylases (2009, unknown): “PGC7/Stella, a DNA-binding protein, helps to protect the maternal genome and specific paternal genes against demethylation (75).”