DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation.

By Mary Gehring, J. Huh, T. Hsieh, Jon Penterman, Yeonhee Choi, J. Harada, R. Goldberg, R. Fischer. Cell, 2006

725 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cb437d87f5615c95f96d0355247f6f7d5ff3cf39

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Citations in the corpus

Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “DNA demethylation relies on the 5-methylcytosine excising activity of the DNA glycosylase DEMETER (DME) (Kinoshita et al., 2004; Gehring et al., 2006) as well as on repression of the maintenance methyltransferase MET1 in the central cell of the female gametophyte and in the endosperm (Jullien et al.”
DNA-methylation changes induced by salt stress in wheat Triticum aestivum (2009, background): “DNA demethylation by DME occurs during reproductive development and is required for genomic imprinting and seed viability (Choi et al., 2002; Gehring et al., 2006; Huh et al., 2008; Makarevich et al., 2008; Tiwaria et al., 2008; Hsieh et al., 2009).”
Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription (2007, background): “Loss of methylation 5′ and 3′ of the MEDEA gene is also correlated with expression in the endosper”
Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis (2007, background): “genes (red boxes, where arrows indicate direction of transcription) that were previously shown to be H3K27me3 targets [”
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine (2011, background): “In plants, a demethylase pathway involving direct removal of 5mC by DNA glycosylase activity has been identified (27, 28), but these proteins do not have mammalian homologs.”
DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 (2008, positive): “Notably, pioneering work in plants provides strong evidence for a set of glycosylase/lyase enzymes (Demeter, ROS, DML2, DML3) in the removal of the 5-meC in various biological contexts (Gehring et al., 2006; Gong et al., 2002; Morales-Ruiz et al., 2006; Penterman et al., 2007).”