The role of RNA interference in heterochromatic silencing

By Z. Lippman, R. Martienssen. Nature, 2004

615 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/0b6db82501e911497c1a61f21aea066e7bb88c9d

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Citations in the corpus

Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. (2006, methodology): “1732 GENES & DEVELOPMENT 20:1732–1743 © 2006 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/06; www.genesdev.org structure (Lippman and Martienssen 2004). rasiRNAs have been cloned and sequenced in Schizosaccharomyces pombe, Trypanosoma brucei, Caenorhabditis elegans, Drosophila…”
Gene silencing in plants using artificial microRNAs and other small RNAs. (2008, background): “…mediate a wide range of phenomena such as transcriptional silencing of heterochromatin and post-transcriptional regulation of mRNA stability, as well as destruction and silencing of invading viral genomes or transgenes (Brodersen and Voinnet, 2006; Lippman and Martienssen, 2004; Vaucheret, 2006).”
Illuminating the silence: understanding the structure and function of small RNAs (2007, background): “A third, less well understood, pathway of RNAi involves heterochromatin silencing by small RNAs (reviewed in Ref”
Steps in the evolution of heteromorphic sex chromosomes (2005, background): “It is possible that a build-up of transposable elements on a proto-Y or neo-Y could reduce gene expression on these chromosomes, through chromatin modification due to dsRNA interference, which is known to be associated with the presence of transposable elements (Lippman and Martienssen, 2004).”
Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs. (2005, background): “The appearance of phenotypes over generations suggested that they re- C A sulted from accumulated epigenetic lesions that occur at the chromatin level, similar to the appearance of phe- f h notypes in ddm1 after three to five generations [15, 16].”
A gene expression map of Arabidopsis thaliana development (2005, background): “Transposons were also underexpressed, consistent with the suggestion that most of them are post-transcriptionally silence”
Origins and Mechanisms of miRNAs and siRNAs (2009, background): “…also exist, however, prominent among them the direct methylation of DNA by DNA methyltransferases (DMTs) in addition to histone methylation (Lippman and Martienssen, 2004) (Figure 3, left) and the involvement of dedicated DNA-dependent RNA polymerases, RNA Pol IV and Pol V, in the…”
DNA transposons and the evolution of eukaryotic genomes. (2007, background): “Although this model was largely overlooked at the time, the explosion of epigenetic research over the past decade has revived these ideas and validated several aspects of the model (120, 178).”
RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. (2011, background): “It 506 has previously been reported that this mode of gene silencing exists in yeast, plants and 507 nematodes, but has not been confirmed to occur in insects (Lippman and Martienssen, 2004).”
The profile of repeat‐associated histone lysine methylation states in the mouse epigenome (2005, background): “…induce formation of double-stranded RNA (dsRNA), which in turn recruits repressive chromatin modifications and DNA methylation to the underlying chromatin template (Tamaru and Selker, 2001; Hall et al, 2002; Volpe et al, 2002; Chan et al, 2004; Lippman and Martienssen, 2004; Verdel et al, 2004).”
Genetic and epigenetic mechanisms for gene expression and phenotypic variation in plant polyploids. (2007, background): “Repeated sequences, whether inverted or tandem, can give rise to the production of dsRNA, an important trigger for RNA silencing as well as heterochromatin formation (85).”
Specialization and evolution of endogenous small RNA pathways (2007, background): “thaliana are implicated in the initiation of DNA methylation and epigenetic contro”