The mitochondrial permeability transition initiates autophagy in rat hepatocytes

By S. Elmore, T. Qian, Sherry F. Grissom, J. Lemasters. The FASEB Journal, 2001

632 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6914528d0471a70a62a2b50174ddd86d10eef54e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. N. Mizushima
2. D. Klionsky
3. Guido Kroemer
4. M. Komatsu
5. T. Yoshimori
6. I. Slaninová
7. Ivan Dikic
8. P. Codogno

In Epidemiology

1. N. Mizushima
2. Beth Levine
3. Guido Kroemer
4. D. Klionsky
5. I. Slaninová
6. M. Komatsu
7. R. Youle
8. Ivan Dikic

In Molecular Biology

1. Guido Kroemer
2. N. Mizushima
3. Beth Levine
4. D. Klionsky
5. R. Youle
6. L. Galluzzi
7. Ivan Dikic
8. Douglas R. Green

Citations in the corpus

• Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. (2007, background): “Autophagy has been reported to promote cell survival in response to stress through both its ability to clear damaged organelles (25) and its ability to recycle intracellular contents to maintain bioenergetics (26).”
• The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “Under certain physiological settings, mitophagy can also eliminate functional mitochondria as seen during erythroid differentiation (106), oocyte fertilization (98), or during starvation (27).”
• Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy (2007, background): “Upregulation of autophagy has been reported to serve as a protective response to various stressors including mitochondrial dysfunction.(31,32) Recently, Yan et al.”
• Autophagy: from phenomenology to molecular understanding in less than a decade (2007, background): “, and subsequent studies confirmed that autophagy could selectively remove this organell”
• Inhibition of Macroautophagy Triggers Apoptosis (2005, background): “1A); LTR is a fluorochrome which measures the volume of the acidic vacuolar compartment (14, 18).”
• ROLE OF BNIP3 AND NIX IN CELL DEATH, AUTOPHAGY, AND MITOPHAGY (2009, neutral): “that BNIP3 and NIX can trigger mitochondrial depolarization, and that mitochondrial depolarization is sufficient to cause mitophagy.(74,75) In support of this model, Sandoval et al.”
• Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation (2011, background): “The increased incidence of mitophagy could suggest that mitochondria from Mfn2-deficient cells are more prone to dysfunction because of the lack of endoplasmic reticulum–mitochondria tethering and altered calcium handling (34) and is consistent with evidence that serum starvation is associated with ”
• Molecular mechanisms and physiological functions of mitophagy (2021, neutral): “Disruption of mitochondrial membrane potential is a potent trigger of mitophagy (Elmore et al , 2001).”
• Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. (2007, background): “…for the 31, 1149–1163, December 14, 2007 ª2007 Elsevier Inc. 1149 turnover of long-lived proteins, disposal of excess (Iwata et al., 2006) or damaged organelles (Elmore et al., 2001), and clearance of aggregate-prone proteins (Fortun et al., 2003; Kamimoto et al., 2006; Ravikumar et al., 2004).”
• Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging (2005, neutral): “10 The beneficial outcome of such autophagy is removal of damaged and free radical–generating mitochondria.”