Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma.

By R. Amaravadi, Duonan Yu, J. Lum, Thi V Bui, M. Christophorou, G. Evan, A. Thomas-Tikhonenko, Craig B. Thompson. Journal of Clinical Investigation, 2007

1,179 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/aecd4d87755cd8d9b3a02a2d5dcb699f1b2a3753

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Citations in the corpus

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. (2007, background): “A recent work highlights the prosurvival role of autophagy in cancer cells (35).”
Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment (2009, positive): “For instance, some studies have shown that autophagy counteracts the antineoplastic effects of therapies including tamoxifen (4), camptothecin (1), cisplatin (118), TNF-a (103), the HDAC inhibitor sub-eroylanilide hydroxamic acid (SAHA) (16), and the alkylating agent cyclophosphamide (4).”
Recent insights into the function of autophagy in cancer (2016, background): “…of cell death observed with shATG5 knockdown versus with various doses of CQ suggests that there may be specific concentrations in each cellular context where CQ is autophagy-selective, and, beyond this concentration, autophagy-independent cytotoxicity may be at play (Amaravadi et al. 2007).”
Autophagy: Renovation of Cells and Tissues (2011, background): “In fact, tumor cell death can be induced in mouse models using drugs that inhibit autophagy (e.g., the lysosome-inhibitory reagent chloroquine) in combination with conventional chemotherapy (Amaravadi et al., 2007; Degtyarev et al., 2008; Yang et al., 2011).”
Blinded by the Light: The Growing Complexity of p53. (2009, background): “Similarly complicated are the consequences of autophagy for tumor suppression, as p53-associated autophagy has been reported to both contribute to apoptosis (Crighton et al., 2006) and help tumor cell survival (Amaravadi et al., 2007).”
Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer (2013, result): “Other studies, however, support the use of autophagy inhibitors as potentiators of anticancer agents.(106,107) As an example, the mammalian target of rapamycin (mTOR) kinase inhibitor everolimus, which induces autophagy, prolonged the survival of patients affected by renal cell carcinoma in a phase-”
Eaten alive: a history of macroautophagy (2010, background): “Accordingly, genetic or pharmacological inhibition of autophagy was shown to enhance the cytotoxicity of cancer chemotherapy agents and to promote tumour regressio”
Role of autophagy in cancer (2007, background): “Preclinical studies with chloroquine, which inhibits lysosome acidification and thereby autophagy, in conjunction with alkylating agents, showed remarkable efficacy inhibiting tumour growth in mic”