Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

By J. Lemasters. Rejuvenation Research, 2005

1,303 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/58849130f5b10debd4fef4bafce0f41a9b0d7302

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Citations in the corpus

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation (2023, background): “Within a few years after the word "mitophagy" was initially proposed [6], substantial developments in this field made it possible to identify crucial proteins that specifically mediate mitochondrial breakdown in yeast [7] and”
Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “Although the exact mechanisms by which autophagy may delay aging are not clear, it has been suggested that mitophagy may help reduce the production of mitochondria-derived ROS and remove dysfunctional mitochondria that would generate mtDNA mutations during aging (Lemasters , 2005 ).”
The mitophagy pathway and its implications in human diseases (2023, background): “Lemasters first proposed mitophagy in 2005, and pointed out that mitochondrial damage is the signal to initiate mitophagy.(10) Parkinson protein 2 (Parkin) was recruited to mitochondrial depolarization when induced by mitochondrial damage to promote autophagic degradation of mitochondria.”
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells (2012, methodology): “(c) HeLa cells were transfected with (Flag)N-Fundc1(1-155)-C(Myc) or (Flag)N-Fundc1(1-139)C(Myc) vectors, respectively.”
The inflammasome: an integrated view (2011, background): “To protect the cell from the damaging effects of excessive ROS, ROS-generating mitochondria are continuously removed by a form of autophagy termed mitophagy (110).”
Toll‐like receptors control autophagy (2008, background): “…issue are complicated by the inherent diversity of autophagic targets, represented by a variety of macromolecules, protein aggregates and an assortment of organelles, including mitochondria (Lemasters, 2005), peroxisomes (Farre and Subramani, 2004) and endoplasmic reticulum (Bernales et al, 2006).”
Molecular mechanisms and physiological functions of mitophagy (2021, positive): “The term “mitophagy” was first coined in 2005 (Lemasters, 2005; Priault et al, 2005), and within a few years, major breakthroughs led to the discovery of key proteins that selectively mediate mitochondrial degradation in yeast (Okamoto et al, 2009; Kanki et al, 2009b) and mammalian cells (Schweers e”
Oxidative modifications to cellular components in plants. (2007, background): “Another possible strategy has been proposed for mammalian cells where a small, biochemically relatively inactive subpopulation of “breeding” mitochondria in each cell is dividing while the biochemically active, and therefore relatively damaged, mitochondria do not divide (57).”