Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis

By E. McMahon, S. Bailey, Carol Vanderlugt Castenada, H. Waldner, S. Miller. Nature Medicine, 2005

702 citations recorded by the source corpus.

Subfields: Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/67e00ee72799fc80760a6a2e136acaa051d694b8

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In Pathology and Forensic Medicine

Citations in the corpus

The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. (2006, background): “We can not exclude the possibility that the rare DCs identified within the gliomas could act as APCs mediating immune responses within the immunosuppressive environment, especially since recent studies in murine experimental allergic encephalomyelitis models have described a minority population of C”
CNS immune privilege: hiding in plain sight (2006, methodology): “(96) performed a set of experiments complementary to those of Greter et al.”
Lymphoid neogenesis in chronic inflammatory diseases (2006, background): “A recent study carried out in two mouse models of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus-induced demyelinating disease, has shown that activation of T cells to endogenous myelin peptides (epitope spreading) occurs in the infla”
Lymphoid organ development: from ontogeny to neogenesis (2006, background): “, T cell epitope spreading in the central nervous system during experimental autoimmune encephalomyeliti”
Tertiary lymphoid structures in cancer (2022, background): “Similarly, in the inflamed central nervous system, TLSs have been found to be involved in local priming of autoreactive T cell responses to endogenous myelin peptides (101).”
From inflammation to sickness and depression: when the immune system subjugates the brain (2008, background): “Elucidation of the temporal dynamics of immune cell recruitment in the brains of mice with EA”
Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury (2009, background): “The subsequent release of previously sequestered myelin antigens may trigger inflammation and induce antigen-specific immune responses in the CNS against myelin proteins, thereby establishing autoimmunity (Bailey et al., 2007; McMahon et al., 2005).”
Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis (2005, background): “, and other studies indicate that epitope spreading occurs exclusively within the inflamed CN”
The myeloid cells of the central nervous system parenchyma (2010, background): “Despite their competence as antigen-presenting cells and their expression of dendritic-cell markers, CNS myeloid cells do not seem to have the capacity to leave the CNS and transport antigen to the lymph nodes, where immune recognition by unprimed T cells could be initiated — and this is the case ev”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “A variant form of adoptive transfer, in which EAE was primed by one myelin epitope and mice with ongoing disease received unprimed TCR transgenic T cells specific for a different epitope, was used to show that myelin-specific T cell proliferation occurred mainly in the CNS after disease onset (111).”