The myeloid cells of the central nervous system parenchyma

By R. Ransohoff, A. Cardona. Nature, 2010

818 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/e555a4594e6a9c1084f3b9530be7141d4f44ade1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. M. Locati
4. Subhra K. Biswas
5. M. Galdiero
6. G. Harry
7. A. Clark
8. C. McPherson

In Neurology

1. G. Harry
2. A. Sica
3. A. Clark
4. Subhra K. Biswas
5. A. Mantovani
6. A. Bessis
7. C. McPherson
8. Rubén Orihuela

Citations in the corpus

• The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “Several mechanisms by which these cells maintain a quiescent state have been proposed, including interaction of microglial CX3CR1 receptor with its neuronal ligand the chemokine CX3CL1 and inhibitory signalling through the microglial cell surface proteins CD172, CD200R and CD45 with their neuronal l”
• Multi-sensory gamma stimulation ameliorates Alzheimer’s-associated pathology and improves cognition. (2019, neutral): “Our results also indicate a range in microglial response that can be elicited by GENUS (Ransohoff and Cardona, 2010) and is supported by accumulating evidence that microglia are heterogeneous and display a spectrum of activated states (Walker and Lue, 2015; Mathys et al.”
• Microglial M1/M2 polarization and metabolic states (2016, background): “state is, in part, due to signals derived from neuronal- and astrocyte-derived factors (Cardona et al., 2006; Neumann et al., 2009; Ransohoff and Cardona, 2010).”
• TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model (2015, neutral): “One of the many effects of Ab deposition is the induction of reactive microgliosis, which involves the expansion of microglia and conversion to an activated state (Ransohoff and Cardona, 2010).”
• Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia (2013, neutral): “Related to this, the investigation of microglia has been complicated by controversy and nomenclature disputes 1–3 and a challenge to investigators has been the development of markers that distinguish microglia from hematogenous infiltrating macrophages which have identical morphologies 2 .”
• The Adverse Effects of Air Pollution on the Nervous System (2012, background): “Microglia cells rapidly change their cell morphology in response to any disturbance of nervous system homeostasis and are then referred to as activated on the basis of morphological changes and expression of cell surface antigens [168].”
• Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission (2011, background): “Microglia is the other major glial cell type of the brain, and its role has mostly been characterized in pathologies (8, 9).”
• Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy (2017, background): “They are scavengers for non-functional synapses [52, 64, 65], and CSF1R-mediated signaling is required both during early CNS development [66] and for survival in adults [67].”
• A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, neutral): “These checkpoint mechanisms include direct inhibitory interactions of microglia with neurons through the receptor-ligand pairs CX3CL1-CX3CR1 and CD200-CD200R, soluble molecules present in the CNS milieu (e.g., transforming growth factor b [TGF-b]), and intracellular regulators such as the transcript”