Lymphoid neogenesis in chronic inflammatory diseases

By F. Aloisi, R. Pujol-Borrell. Nature reviews. Immunology, 2006

962 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/21a4c9c7a4232c6423d79aa61c4e83f94a9f5900

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In Immunology

1. Hans Lassmann
2. H. Spits
3. W. Fibbe
4. R. Förster
5. N. Crellin
6. F. Aloisi
7. A. Rot
8. R. Ransohoff

Citations in the corpus

• Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells (2009, background): “In addition, in several human inflammatory diseases, infiltrating lymphocytes are arranged in organized tertiary lymphoid organ”
• Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis (2019, background): “In the meninges and perivascular space this inflammatory reaction is present diffusely but it may form focal aggregates or structures, which resemble tertiary lymph follicles with clearly separated T-cell, Bcell and plasma cells areas (111).”
• Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. (2008, background): “In RA, Crohn's disease and other chronic immune-mediated inflammatory diseases, similar organized lymphoid structures, such as ectopic germinal centers and B-cell follicles, are seen within the inflamed tissue (Gommerman & Browning, 2003; Aloisi & Pujol-Borrell, 2006).”
• Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes (2010, neutral): “Why are RORgt NKR-LTi cells such potent inducers of colitis? An important pathological feature of colitis, as well as of other chronic inflammatory processes, are de novo generated proinflammatory leukocyte clusters (Aloisi and Pujol-Borrell, 2006; Izcue et al., 2009).”
• Reactive Oxygen Species in Inflammation and Tissue Injury (2014, neutral): “Certain chronic inflammatory conditions such as rheumatoid arthritis, psoriasis, Hashimoto’s thyroditis, Crohn’s disease, ulcerative colitis, and multiple sclerosis are accompanied by development of HEVs in normal organs, facilitating a large influx of lymphocytes that contribute to chronic inflamma”
• CCR7 and its ligands: balancing immunity and tolerance (2008, background): “Such lymphoid structures are frequently observed in lesions of Sjogren's syndrome , rheumatoid arthritis and autoimmune thyroditis, and are thought to maintain local chronic autoimmune responses that favour disease progressio”
• Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. (2007, background): “Formation of ectopic lymphoid tissue has been observed in several chronic inflammatory diseases with an autoimmune or infectious aetiology and is thought to be induced by the persistent inflammatory milieu of the target tissue (Aloisi and Pujol-Borrell, 2006).”
• The Immunopathology of Multiple Sclerosis: An Overview (2007, background): “Similar follicle-like structures are also found in other chronic inflammatory diseases, such as Hashimoto thyroiditis (5).”
• Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. (2011, background): “The pathophysiological role of these ectopic or tertiary lymphoid tissues is still unclear , but it is thought that these structures may represent a local source of pro-inflammatory mediators, autoantibodies and self-reactive T cells (Aloisi and Pujol-Borrell, 2006; Carragher et al., 2008).”