Stem cells, cancer, and cancer stem cells

By T. Reya, S. Morrison, M. Clarke, Irving L. Weissman. Nature, 2001

9,275 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/65f48a229bc74ee37e95b00756727991f536f6ec

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Citations in the corpus

Cancer and the chemokine network (2004, background): “, and CXCR4 expression by a sub-population of cells in a primary cancer indicates that these cells might be cancer stem cell”
Normal stem cells and cancer stem cells: the niche matters. (2006, background): “Only a few cells within the tumor, the cancer stem cells, are tumorigenic and possess the metastatic phenotype (5).”
iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway (2018, background): “These CSCs can differentiate into other tumor cell populations and seed the tumor in xenografts or at metastatic sites (19).”
Mechanisms of asymmetric stem cell division. (2008, background): “Neuroblasts as a Cancer Stem Cell Model It has recently become clear that many tumors are maintained by a small fraction of so-called cancer stem cells that give rise to all the other cells present in the tumor (Reya et al., 2001).”
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells (2004, background): “Our work could have repercussions outside the field of haematology, because the signalling pathways regulating stem cell self-renewal might also be used by cancer cells to drive malignant proliferatio”
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. (2011, background): “The second school proposes that progenitor or stem cells, residing within the tissue, accumulate oncogenic properties and transform into cells, which initiate the tumor.(107,108) Recent studies point to a new role for WT p53 in balancing both differentiation and de-differentiation in a cell type– an”
Identification of human brain tumour initiating cells (2004, background): “jpg" NDATA ITEM> ]> The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with stem cell propertie”
Brain tumour stem cells (2006, background): “The stochastic model predicts that all the cells in a tumour have a similar tumorigenic potential, which is activated asynchronously and at a low frequency in certain cell”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Over the past several years, it has become clear that the growth of at least some cancers is driven by cancer stem cells, particularly malignant cancer cells that are more tumorigenic than other cancer cells (Pardal et al., 2003; Reya et al., 2001).”
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. (2012, neutral): “This is also popularly known as the cancer stem cell (CSC) model (Reya et al., 2001; Rosen and Jordan, 2009).”
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. (2004, background): “…suggested that the target cells for malignant Philadelphia chromosome, the cytogenetic hallmark of CML,transformation are adult somatic stem cells (Reya et al., 2001), can be detected in cells of the myeloid, erythroid, megakaryo-and that oncogenic mutations appropriate the capacity for…”