Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

By Wen Cai Zhang, Ng Shyh‐Chang, Hen-Ying Yang, A. Rai, S. Umashankar, Siming Ma, B. Soh, Li Li Sun, B. Tai, M. Nga and 19 more. Cell, 2012

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Cancer stem cells: current status and evolving complexities. (2012, positive): “In a metabolic context, glycine decarboxylase was demonstrated to regulate the activity of tumor-propagating cells in non-small cell lung cancer (Zhang et al., 2012).”
Links between metabolism and cancer. (2012, background): “Glycine decarboxylase (GLDC) is another enzyme that was recently implicated as an oncogenic enzyme, which is involved in glycine/serine metabolism and the onecarbon metabolic pathway (Zhang et al. 2012).”
Targeting cancer stem cell pathways for cancer therapy (2020, background): “The heterogeneity of CSCs has also been found in other cancers, including glioblastoma,(41) prostate cancer,(42) and lung cancer.(43) The heterogeneity of CSCs is so complex that more effective biomarkers are needed to identify CSCs or distinguish the heterogeneity of CSCs.”
Cancer Cell Metabolism: One Hallmark, Many Faces (2012, neutral): “Another recent report described the identification of a molecular signature for the tumor initiating cells (TICs) of non-small lung cancer (NSCLC) (100).”
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate (2012, background): “Additional proposed functions include the generation of precursors for pyrimidine synthesis and the production of sarcosine, a glycine-derived metabolite linked to prostate cancer progression (Sreekumar et al., 2009; Zhang et al., 2012).”