MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

By B. Huntly, Hirokazu Shigematzu, Kenji Deguchi, Benjamin H. Lee, S. Mizuno, Nicky Duclos, R. Rowan, Sonia M Amaral, D. Curley, I. Williams and 2 more. Cancer Cell, 2004

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To better understand the origin of leukemic stem cells, we tested the hypothesis that all leukemia oncogenes could transform committed myeloid progenitor cells lacking the capacity for self-renewal, as has recently been reported for MLL-ENL. Flow-sorted populations of common myeloid progenitors and granulocyte-monocyte progenitors were transduced with the oncogenes MOZ-TIF2 and BCR-ABL, respectively. MOZ-TIF2-transduced progenitors could be serially replated in methylcellulose cultures and continuously propagated in liquid culture, and resulted in an acute myeloid leukemia in vivo that could be serially transplanted. In contrast, BCR-ABL transduction conferred none of these properties to hematopoietic progenitors. These data demonstrate that some, but not all, leukemia oncogenes can confer properties of leukemic stem cells to hematopoietic progenitors destined to undergo apoptotic cell death.

Subfields: Hematology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/019c82782b6d079730977f6652ebae63e81373d3

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Citations in the corpus

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. (2011, neutral): “In human acute leukemia, this crucial property can be acquired by committed progenitors with limited self-renewal capacities through a genetic event or maintained through the targeting of hematopoietic stem cells (HSCs) (Cozzio et al., 2003; Goardon et al., 2011; Huntly et al., 2004).”
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition (2008, background): “. Additionally, committed hematopoietic progenitor cells, with no inherent self-renewal properties, can be induced to generate cells capable of initiating and maintaining leukemias using leukemogenic fusion proteins”
Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, background): “The properties of the cell-of-origin influence the types of mutations that are competent to transform and the properties of the resulting cancer (Huntly et al., 2004; Wang et al., 2010).”
Stems cells and the pathways to aging and cancer. (2008, background): “In mouse models, expression of BCR-ABL was not sufficient to confer the properties of LSCs on committed progenitors, whereas ectopic expression of the MOZ-TIF2 oncogene that induces self-renewal was sufficient (Huntly et al., 2004).”
Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia (2005, neutral): “DH p185 (1-426) p210 (1-902–927) p230 (1–1,176) Y177 Myr GAG BCR F G 1a 1b”
The biology of cancer stem cells. (2007, background): “…lacking the ability to selfrenew , more recent evidence suggests that in many cancers the cancer stem cells arise from progenitor cells that have gained the ability to self-renew (Cozzio et al. 2003, Huntly et al. 2004, Krivtsov et al. 2006, Lavau et al. 1997, So et al. 2004, Wagner et al. 2006).”
Radial glia cells are candidate stem cells of ependymoma. (2005, background): “Proof of principle that self-renewal can be reestablished has been provided by experiments in which the transduction of hematologic cells with MOZ-TIF2 restored self-renewal and promoted leukemogenesis (Huntly et al., 2004).”