Revisiting the principles of microRNA target recognition and mode of action

By P. Brodersen, Olivier Voinnet. Nature reviews. Molecular cell biology, 2009

705 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/0f057766e617431fd7be9a8319a8ddc03fea3c5c

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Citations in the corpus

Non‐coding RNAs: regulators of disease (2010, background): “A detailed examination of miRNA biogenesis and function is beyond the scope of this work and has recently been covered in detail in several excellent reviews [16,17,60].”
psRNATarget: a plant small RNA target analysis server (2011, background): “Complementarity and target-site accessibility have been proven to be the two key factors in the plant regulatory small RNA (miRNA and ta-siRNA) target recognition mechanism (19–21).”
RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. (2011, background): “For instance, it 654 is known that siRNAs produced can interfere with other small RNA pathways such as the 655 miRNA pathway (Brodersen and Voinnet, 2009) and that dsRNA can induce the innate 656 immune response through interaction with Toll-like receptors, at least in vertebrates.”
TAPIR, a web server for the prediction of plant microRNA targets, including target mimics (2010, background): “Recent studies have shown that translational repression mediated by miRNAs is more frequent than previously thought in plants (Brodersen et al., 2008; Brodersen and Voinnet, 2009; Dugas and Bartel, 2008).”
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease (2013, neutral): “Glimpses of evidence supporting the ‘expanded’ model were also observed experimentally in earlier work as well as discussed in the literature.(110,112,124,130,142) The members of miR-17/92 clusters are ideal miRNAs for which to explore ‘unexpected targets’ under the ‘expanded’ model.”
MicroRNA control of signal transduction (2010, background): “Within the RISC, the single-stranded miRNA is unwound by the helicase activity of Dicer and guides target selection, causing inhibition of translation, stability and localization of target mRN”
Genome-wide identification and analysis of drought-responsive microRNAs in Oryza sativa. (2010, background): “In fact it is no longer true that mRNA cleavage is the predominant mechanism in plants since translation inhibition has recently been shown to be widespread (Brodersen and Voinnet, 2009).”
miRNAs in human cancer (2010, background): “miRNA biogenesis has been reviewed extensively [47,58–64] (Figure 1).”
Desperately seeking microRNA targets (2010, background): “The mature miRNA guides the miRISC to partially complementary sequences, termed miRNA recognition elements (MREs), in target mRNAs to repress mRNA translation, promote transcript decay or bot”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “Other factors include the number of target sites for the same miRNA and relative position of them, site accessibility, sequences flanking miRNA target site, and their context, and RNA secondary structure can influence the consequences of hybridization [62–64].”