Gene silencing by microRNAs: contributions of translational repression and mRNA decay
By Eric Huntzinger, Elisa Izaurralde. Nature reviews genetics, 2011
2,407 citations recorded by the source corpus.
Subfields: Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/5512f1ede01c5e4f6950d9f76ea4baf6f496655f
How researchers see this paper
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In Molecular Biology
- David P. Bartel
- Artemis G. Hatzigeorgiou
- Thomas Tuschl
- Vikram Agarwal
- Pavel Morozov
- T. Farazi
- Charles E. Vejnar
- E. Zdobnov
In Plant Science
- David P. Bartel
- Thomas Tuschl
- Artemis G. Hatzigeorgiou
- Vikram Agarwal
- Ioannis S. Vlachos
- Maria D. Paraskevopoulou
- Thanasis Vergoulis
- Charles E. Vejnar
Citations in the corpus
- Development of microRNA therapeutics is coming of age (2014, neutral): “Metazoan miRNAs guide the miRISC to target mRNAs by base pairing imperfectly with their 3 0 untranslated regions (UTRs), leading to translational repression and/or degradation of the mRNA targets (Fig 1) (Krol et al , 2010; Huntzinger & Izaurralde, 2011).”
- A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. (2015, background): “It is known that miRNAs may degrade mRNAs with poly A tails via a miRNA-directed deadenylation pathway (Huntzinger and Izaurralde, 2011) and NKILA is such”
- DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts (2015, methodology): “Queries using one or more microRNAs and/or lncRNAs [1] or even the coordinates of a genomic location [2] are supported.”
- DIANA-miRPath v3.0: deciphering microRNA function with experimental support (2015, background): “From the new interface, users can select the pathway/GO category of interest [1] and the interactions database [2].”
- MicroRNAs in human cancer. (2013, background): “An excellent recent review describes the different mechanisms implicated in miRNA function, highlighting the different experiments supporting translational repression versus mRNA decay and the evolution in our current thinking [107].”
- Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “induce translational repression and mRNA deadenylation and decapping (40, 41).”