The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

By M. Fabian, Nahum Sonenberg. Nature Structural &Molecular Biology, 2012

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Molecular mechanisms of RNA interference (2013, positive): “PABP binds the 3′ poly(A) tail of mRNA and recruits PAIP1 and eIF4G to promote translation initiation via mRNA circularization (21).”
An overview of microRNAs (2015, background): “The CCR4-NOT deadenylase complex is recruited to RISC and this facilitates removal of the poly(A) tail and eventual degradation of the mRNA target [77-79].”
The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs (2013, background): “Let-7 regulates target gene expression by binding to imperfectly complementary sequences in mRNAs, leading to translational repression and/or mRNA destabilization (Fabian and Sonenberg, 2012).”
MicroRNA and cancer (2012, background): “The mature miRNA then induces posttranscriptional gene silencing by tethering RISC to partly complementary sequence motifs in target mRNAs predominantly found within the 30 untranslated regions (UTRs) (Figure 1) (Bartel, 2009; Fabian and Sonenberg, 2012; Saj and Lai, 2011).”