Mitochondrial dynamics in health and disease: mechanisms and potential targets
By Wen Chen, Huakan Zhao, Yongsheng Li. Signal Transduction and Targeted Therapy, 2023
1,078 citations recorded by the source corpus.
Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity and dynamic nature. These abilities allow them to effectively coordinate various cellular functions. Mitochondrial dynamics refers to the changing process of fission, fusion, mitophagy and transport, which is crucial for optimal function in signal transduction and metabolism. An imbalance in mitochondrial dynamics can disrupt mitochondrial function, leading to abnormal cellular fate, and a range of diseases, including neurodegenerative disorders, metabolic diseases, cardiovascular diseases and cancers. Herein, we review the mechanism of mitochondrial dynamics, and its impacts on cellular function. We also delve into the changes that occur in mitochondrial dynamics during health and disease, and offer novel perspectives on how to target the modulation of mitochondrial dynamics.
Subfields: Clinical Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5ed198eb97009555a637fc354ef55d9681184347
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Citations in the corpus
- Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies (2024, background): “Alterations in the expression levels of proteins related to fi ssion/fusion processes (such as Opa1, Drp1, MFN1/2, Fis1) 298 and post-translational modi fi cations of Drp1 299,300 may bias mitochondria towards excessive fi ssion, increasing mitochondrial fragmentation, leading to damage in…”