Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

By Huei-Fen Jheng, P. Tsai, Syue-Maio Guo, L. Kuo, Cherng-Shyang Chang, I. Su, Chuang-Rung Chang, Y. Tsai. Molecular and Cellular Biology, 2011

608 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4318951dc3453970d52735b16951b99f27ec8636

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. Wen Chen
2. Yongsheng Li
3. Huakan Zhao

In Molecular Biology

1. Wen Chen
2. Yongsheng Li
3. D. Luciani
4. Huakan Zhao
5. A. Chaudhry
6. Rocky Shi

Citations in the corpus

• A pipeline for multidimensional confocal analysis of mitochondrial morphology, function and dynamics in pancreatic β-cells (2019, background): “Perturbations to mitochondria 66 are also a common feature in insulin target tissues with impaired insulin signaling (11, 12).”
• PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “On the other hand, Drp1 and Fis1 were increased in liver from db/db mouse as well as in mice with high-fat diet-induced obesity, resulting in impaired mitochondrial function [177].”
• Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “On the other hand, research in skeletal muscle from mice indicates that a rise of mitochondrial fragmentation is related to an impaired insulin response and dysfunctional mitochondria.(148) Together the available research suggests that the impact of stimulating mitochondrial splitting on mitochondri”
• New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis (2018, background): “Other effects of hyperglycemia that increase ROS production include an increased NADH/FADH2 ratio and increased mitochondrial fission with accumulation of fragmented mitochondria with impaired electron transport chain activity [21,22].”
• Insulin receptor signaling in normal and insulin-resistant states. (2014, background): “Besides the aspect of ROS-mediated insulin resistance, altered mitochondrial dynamics in the form of increased mitochondrial fission leads to insulin resistance and can be rescued by inhibiting fission, which decreases the activity of p38 MAP kinase and increases IRS-1 and Akt activation (Jheng et a”
• Pathophysiology of Type 2 Diabetes Mellitus (2020, background): “Furthermore, increased mitochondrial fission and mitochondrial fragmentation have been associated with mitochondrial depolarization, impaired ATP production and decreased insulin-dependent glucose uptake as well as increased mitochondrial ROS and impaired insulin signalling in C2C12 murine cell line”
• Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “297 Conversely, inhibiting Drp1 activity and reducing mitochondrial fi ssion improved mitochondrial function and restored insulin signaling.”