Mitochondria in innate immune responses
By A. West, G. Shadel, S. Ghosh. Nature reviews. Immunology, 2011
1,292 citations recorded by the source corpus.
The innate immune system has a key role in the mammalian immune response. Recent research has demonstrated that mitochondria participate in a broad range of innate immune pathways, functioning as signalling platforms and contributing to effector responses. In addition to regulating antiviral signalling, mounting evidence suggests that mitochondria facilitate antibacterial immunity by generating reactive oxygen species and contribute to innate immune activation following cellular damage and stress. Therefore, in addition to their well-appreciated roles in cellular metabolism and programmed cell death, mitochondria appear to function as centrally positioned hubs in the innate immune system. Here, we review the emerging knowledge about the roles of mitochondria in innate immunity.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4822f320fac5f6b198e75f1ada4bfda5a1422a9a
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In Immunology
In Molecular Biology
- Navdeep S. Chandel
- S. Weinberg
- G. Shadel
- T. Horvath
- Laura A. Sena
- Michael Schieber
- Ralph J. Deberardinis
Citations in the corpus
- Mitochondrial ROS signaling in organismal homeostasis. (2015, background): “…including wound healing (Xu and Chisholm, 2014), survival under hypoxia (Schieber and Chandel, 2014), intracellular pH homeostasis (Johnson et al., 2012), cell differentiation (Hamanaka and Chandel, 2010; Hamanaka et al., 2013; Tormos et al., 2011), and innate immunity (West et al., 2011).”
- Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling (2013, neutral): “becoming clear in innate immunity, given that mROS appear to be essential for a wide range of innate immune function, including antiviral, antibacterial, and antiparasitic responses (West et al., 2011b).”
- ROS Function in Redox Signaling and Oxidative Stress (2014, background): “In the past two decades, substantial evidence has revealed that ROS are essential second messengers in innate and adaptive immune cells [73,74].”
- Reactive oxygen species and mitochondria: A nexus of cellular homeostasis (2015, background): “Depending on the context and triggering stimuli, mtROS production can lead to different cellular responses such as cellular adaptation to hypoxia [43], cellular differentiation [44], autophagy [5], inflammation [45], or an immune response [6].”
- Mitochondria in the regulation of innate and adaptive immunity (2015, positive): “Mitochondrial DNA is similar to bacterial DNA in that both share hypomethylated CpG motifs, which activate TLR9 (West et al., 2011a).”