Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.

By O. Gavrilova, B. Marcus‐Samuels, D. Graham, Jason K. Kim, Gerald I. Shulman, A. Castle, C. Vinson, Michael Eckhaus, M. Reitman. Journal of Clinical Investigation, 2000

679 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/5c7c8b874e8599d8d644179612ab3ed1079d60e0

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Citations in the corpus

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. (2015, background): “Similarly, central or peripheral leptin administration decreases insulin resistance, steatosis and glucose in generalized lipoatrophy [91–93].”
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “Surgical transplantation of adipose tissue into these lipotrophic animals results in mobilization of fat out of the liver and muscle, improved insulin sensitivity in these organs, and correction of the glucose intolerance (246).”
Disordered lipid metabolism and the pathogenesis of insulin resistance. (2007, neutral): “One way to reduce ectopic lipid deposition in lipodystrophic mice is to transplant adipose tissue from wild-type mice, a procedure which dramatically improved insulin sensitivity (38, 53).”
Identification of white adipocyte progenitor cells in vivo. (2008, background): “It has previously been shown that the transplant of 900 mg of normal adult WAT into A-Zip mice is required for correction of their insulin resistance and hyperglycemia (Gavrilova et al., 2000) and that transplants of smaller amounts of adipose tissue failed to correct diabetes in these animals.”
Obesity and the role of adipose tissue in inflammation and metabolism. (2006, background): “These experiments provided an elegant platform for the argument that fat cells play a role in health (3).”
Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. (2002, background): “Furthermore, all aspects of the fatless mouse phenotype are alleviated in a dose-response fashion with surgical implantation of adipose tissue (81).”
Abdominal obesity and metabolic syndrome (2006, background): “Consistent with this theory is the fact that transgenic mice that are essentially fatless owing to the expression of A-ZIP/F-1 protein — which blocks the activity of several transcription factors — also show liver and muscle insulin resistance and eventually develop diabete”
Beneficial effects of subcutaneous fat transplantation on metabolism. (2008, background): “Likewise, increasing subcutaneous fat by transplanting visceral fat to the subcutaneous area of lipoatrophic mice improves their metabolic profile rather than making it worse (Gavrilova et al., 2000).”
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. (2001, background): “” In fact, lack of adipose tissue appears to result in impaired insulin action due at least in part to the lack of adipose-derived circulating proteins, such as leptin (4, 32, 38).”
Adipose tissue as a buffer for daily lipid flux (2002, background): “Paradoxically, a deficiency of adipose tissue, as in lipodystrophy or lipoatrophy in humans [6, 7] and rodents [8, 9, 10], is also associated with insulin resistance.”
Obesity and insulin resistance. (2000, background): “adipose loss, leptin replacement transiently ameliorated but did not reverse the disorder, whereas fat transplantation dramatically reversed insulin resistance and diabetes (53).”