Adipose tissue as a buffer for daily lipid flux

By K. Frayn. Diabetologia, 2002

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Insulin Resistance: From Mechanisms to Therapeutic Strategies (2021, background): “In lipodystrophy, postprandial fatty acid influx cannot be buffered by adipose tissue, and as a result fatty acids are delivered to other metabolic tissues, including liver and skeletal muscle, which impairs insulin signaling and causes severe insulin resistance [94].”
Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. (2006, background): “Because of their hydrophobic properties, LCFAs are transported in blood by albumin and oxidized by most tissues to provide ATP except in the brain [48].”
Pathophysiology of human visceral obesity: an update. (2013, background): “Such findings demonstrate that metabolic alterations may arise from reduced adipose tissue expandability when facing caloric excess and spillover of lipids to other tissues such as the liver and muscle (162, 192, 386, 454) (FIGURE 8).”