Obesity and insulin resistance.

By B. Kahn, J. Flier. Journal of Clinical Investigation, 2000

1,681 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/b58d49ea2b03e2f18e34edb2a9de374f1eba4393

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Jamal Naderi
2. M. Longo
3. C. Miele
4. G. A. Raciti
5. F. Beguinot
6. Federica Zatterale
7. I. Shimomura

In Physiology

1. Jamal Naderi
2. M. Longo
3. C. Miele
4. G. A. Raciti
5. F. Beguinot
6. Federica Zatterale

Citations in the corpus

• Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes (2020, background): “Obesity association with T2D has long been recognized, and the primary reason is the ability of obesity to promote IR, the main pathophysiological aspect of T2D (Kahn and Flier, 2000).”
• Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. (2013, background): “Altered levels of dipocytokines may play a role in the pathoenesis of obesity-associated diseases [2,37,38].”
• Association between insulin resistance and the development of cardiovascular disease (2018, background): “These changes may contribute to increased basal lipolysis in obesity and the release of fatty acids into the circulation that consequences a proatherogenic phenotype [19, 90].”
• Insulin resistance: Review of the underlying molecular mechanisms (2018, background): “Insulin plays an important role in adipocytes, as they are the most insulin‐dependent cells in obese humans (Kahn & Flier, 2000).”
• Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. (2008, background): “Although SHBG was negatively associated with increasing strata of obesity, the positive relationship with age was well preserved in obese as well as in the nonobese men, clearly demonstrating the concurrent but opposite (and separate) effects of obesityandageonSHBG(27).Obesityisassociatedwithinsulin”