Obesity and the role of adipose tissue in inflammation and metabolism.

By A. Greenberg, M. Obin. American Journal of Clinical Nutrition, 2006

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Exercise and mental health. (2017, background): “As a person becomes larger and adipocytes increase in size, dysregulation occurs which can predispose the person to insulin resistance and metabolic disorders [118].”
High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse (2010, background): “It is now widely accepted that obesity is associated with lowgrade chronic inflammation and that inflammation contributes to risk of insulin resistance and type 2 diabetes as well as other detrimental health consequences linked to obesity [1,2,3].”
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. (2007, background): “Introduction Recent investigations suggest that obesity gives rise to a state of chronic, low-grade inflammation that contributes to insulin resistance and type 2 diabetes (1, 2).”
Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “Visceral adipose tissue and pro-inflammatory factors including IL-6, TNF-α, and interferon-γ (IFN-γ) increase with age (Greenberg and Obin, 2006) and, partly because these inflammatory factors are produced and regulated by fat tissue (Vick et al., 2007).”