Disordered lipid metabolism and the pathogenesis of insulin resistance.

By D. Savage, K. Petersen, Gerald I. Shulman. Physiological Reviews, 2007

1,122 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/cfe1df09de88f84f92dbe78c17c8dfc35e2dc65b

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Citations in the corpus

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites (2010, background): “Triglyceride accumulation in the liver was once thought to impair insulin signaling and be a cause of insulin resistance in the liver and muscle.(8,142,143) However, newer data have convincingly shown that triglyceride does not impair insulin signaling just as it does not cause lipotoxic injury; ins”
Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease (2011, background): “, 2008) would provide a plausible basis for the development of NAFLD during insulin resistance (Savage et al., 2007).”
Fatty acid-induced NLRP3-PYCARD inflammasome activation interferes with insulin signaling (2011, positive): “Overload of FFAs directly exerts a lipotoxic effect through an increase in intracellular lipid metabolite”
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity (2009, background): “Likewise, chronic inflammation also impairs triglyceride storage in adipose tissues, and the excess circulating free fatty acids and triglycerides also induces insulin resistance in muscle and live”
FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine (2013, background): “Knowing the importance of the role of adipose tissue on energy homeostasis and its participation in obesity [33,34], the discovery of FNDC5/irisin as a new adipokine described in our manuscript suggests an autocrine and most likely an endocrine function for this peptide in adipose tissue.”
Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “A hypothesis is that FXR deficiency promotes ectopic lipid deposition in insulin target tissues, a phenomenon usually referred to as “lipotoxicity” (264).”
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes (2008, result): “The hypothesis that FFAs mediate insulin resistance is consistent with data that show a strong association of obesity and insulin resistance with high circulating FFA level”
The Pleiotropic Actions of Adiponectin are Initiated via Receptor-Mediated Activation of Ceramidase Activity (2010, background): “Ceramide and its glycerol-based counterpart, diacylglycerol (DAG), correlate with impaired insulin action in muscl”
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response (2009, background): “Decreasing hepatic fatty acid content has well-documented effects on liver insulin sensitivity in a variety of models and indirectly improves the responsiveness of hepatic glucose production, via either glycogenolysis or gluconeogenesis (38, 39).”
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. (2011, background): “resistant, a metabolic state which predisposes individuals to cardiovascular disease and diabetes (1, 2).”
Fibrosis and Adipose Tissue Dysfunction (2013, background): “The rigid nature of these fibrotic fat pads prompts limited physical andmetabolic flexibility, resulting in ectopic lipid deposition in peripheral tissues, such as the muscle and in the liver (Savage et al., 2007).”