Endogenous glucose production is inhibited by the adipose-derived protein Acrp30.

By Terry P. Combs, A. Berg, S. Obici, P. Scherer, L. Rossetti. Journal of Clinical Investigation, 2001

944 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/c0526937a6b88ba4f7f96de1d2b4e878383770a6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Physiology

In Surgery

Citations in the corpus

Adipose Tissue (2006, neutral): “Early studies using euglycemic clamp techniques indicated that adiponectin, when injected in a recombinant form, has a profound impact on the liver (20).”
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis Through Adipose Tissue Crosstalk (2016, background): “…numerous tissues and cell types as an insulin-sensitizing, antiapoptotic, and anti-inflammatory peptide secreted by adipocytes (Berg et al., 2001; Combs et al., 2001, 2004; Holland et al., 2011), coupled with the discovery of leptin just 1 year prior (Zhang et al., 1994) and its…”
The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. (2003, background): “…of Acrp30, comprising the induction of free fatty acid oxidation, body weight reduction in mouse (Fruebis et al., 2001), hyperglycemia (Berg et al., 2001; Combs et al., 2001), hyperinsulinemia decrease, and insulin resistance reversion (Yamauchi et al., 2001) in obese and diabetic animals.”
SirT1 gain-of-function increases energy efficiency and prevents diabetes in mice (2008, neutral): “Based on prior evidence that adiponectin increases hepatic insulin sensitivity (Combs et al., 2001), we analyzed the role of adiponectin in our transgenic model.”
Adiponectin: mechanistic insights and clinical implications (2012, background): “As mentioned above, murine euglycaemic clamp experiments have shown no difference in rates of glucose disappearance, glycolysis or glycogen synthesis in the presence or absence of intravenous adiponectin infusion [49], again highlighting adiponectin’s main effect, which is to lower blood sugar by su”
Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.M400373-JLR200 (2005, background): “Adiponectin has been shown to augment lipid oxidation in skeletal muscle and myocytes (8, 9) and to reduce hepatic glucose production in liver and hepatocytes (10, 11).”
Adipose tissue-derived factors: impact on health and disease. (2006, background): “results in glucose lowering due to decreased hepatic glucose output and suppression of gluconeogenic genes (92, 93).”
Adiponectin: more than just another fat cell hormone? (2003, background): “This was associated with a reduced expression of the gluconeogenic enzymes PEPCK and glucose-6-phosphatase (G6Pase), indicating that transcriptional regulation of these two enzymes may contribute to the molecular mechanism of action of adiponectin (36).”
AMPK in Health and Disease. (2009, methodology): “The mammalian AMPK domain limits were established experimentally by partial proteolysis (395), and a stable rat 1(68-163) fragment was expressed and crystallized in the presence of -cyclodextrin (an 1-4 linked heptaglucan), as had previously been performed for other starch binding domain structural ”