GENERATION OF GERMLINECOMPETENT INDUCED PLURIPOTENT STEM CELLS

By K. Okita, T. Ichisaka. 2007

671 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5b98acc438f60861c6427a01db6d0e4488bff6b1

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Citations in the corpus

Induced pluripotency: history, mechanisms, and applications. (2010, background): “The reactivation of endogenous pluripotency-associated genes—such as Fbxo15 (Takahashi and Yamanaka 2006), Nanog or Oct4 (Maherali et al. 2007; Okita et al. 2007; Wernig et al. 2007), and Utf1 (Pfannkuche et al. 2010)—linked to drug selection cassettes has been successfully employed for this…”
Oct4-induced pluripotency in adult neural stem cells. (2009, unknown): “The estimated reprogramming efficiency for the one-factor approach can be calculated as 0.014%, which is 10-fold lower than our two-factor approach (Kim et al., 2008) and similar to reprogramming MEFs with four factors (Okita et al., 2007).”
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. (2008, methodology): “expression of the transcription factors Oct4 and Sox2, combined with Klf4 and c-Myc (Maherali et al., 2007; Okita et al., 2007; Park et al., 2008; Takahashi et al., 2007; Wernig et al., 2007) or Lin28 and Nanog (Yu et al.”
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. (2010, background): “Mouse iPSCs are similar to ESCs in most aspects and can generate entire individuals after tetraploid complementation (Kang et al., 2009; Okita et al., 2007; Wernig et al., 2007; Zhao et al., 2009).”
Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009, background): “It has been demonstrated in the mouse system that iPSC-derived chimeras frequently develop tumors resulting from reactivation of the oncogene c-Myc (Markoulaki et al., 2009; Okita et al., 2007).”
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. (2012, background): “Fully reprogrammed induced pluripotent stem cells (iPSCs) can contribute to the three germ layers and give rise to fertile mice by tetraploid complementation (Okita et al., 2007; Zhao et al., 2009).”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, unknown): “…achieved a breakthrough in this field by demonstrating that the overexpression of four transcription factors, Oct4, Sox2, Klf4, and c-Myc, can convert somatic fibroblasts to pluripotent cells (iPSCs) that can contribute to the germline in chimeric mice (Okita et al., 2007; Wernig et al., 2007).”
A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog (2009, background): “Retroviral transduction with three genes, Sox2, Oct4, and Klf4, can directly reprogram somatic cells to a pluripotent stem cell state (Okita et al., 2007; Takahashi et al., 2007b).”
Reprogramming of mouse and human cells to pluripotency using mature microRNAs. (2011, methodology): “We introduced the miRNAs into mASCs obtained from Nanog promoter-driven green fluorescent protein (GFP) reporter mice (Okita et al., 2007).”
An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “…Sox2)(Boyer et al., 2005; Loh et al., 2006), somatic cell reprogramming factors (Klf4 and Myc, in addition to Oct4 and Sox2) (Maherali et al., 2007; Okita et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2007b), and protein-interacting partners of Nanog and Oct4 (Dax1, Nac1, Zfp281 and…”
Generation of germline-competent induced pluripotent stem cells (2007, background): “In the July 2007 issue of Nature, Keisuke Okita, Tomoko Ichisaka, and Shinya Yamanaka added to the new work on induced pluripotent stem cells (iPSCs) with their "Generation of Germline-Competent Induced Pluripotent Stem Cells" (henceforth abbreviated "Generation").”
Epigenetic reprogramming and induced pluripotency (2009, background): “Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.”
Origin and differentiation of microglia (2013, background): “The exciting discovery that terminally-differentiated somatic cells can be reprogrammed into an embryonic-like “induced pluripotent stem cell” (iPSC) has also opened up new possibilities for disease modeling and developing patient-specific therapies (Takahashi and Yamanaka, 2006; Okita et al., 2007;”