Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.

By M. Esteban, Tao Wang, Baoming Qin, Jiayin Yang, Dajiang Qin, Jinglei Cai, Wen Li, Zhihui Weng, Jiekai Chen, Su Ni and 16 more. Cell Stem Cell, 2010

967 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/92c6c746c020c8d1b9a9444934890d1fa1418bfe

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Citations in the corpus

Reprogramming of mouse and human cells to pluripotency using mature microRNAs. (2011, background): “Since the initial description of this approach, numerous studies have described modifications of the original protocol using additions or alternatives to these factors, including small molecules, with the aim of improving the efficiency and/or moving it toward potential clinical application (for exa”
Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment (2017, methodology): “Human ASM cells were infected as described [14], to establish ADAM33 overexpressing ASM cells (ASM cells-ADAM33), and ASM cells infected with retrovirus containing blank pMXs vector (ASM cellsvector) were used as the control group.”
Nuclear reprogramming to a pluripotent state by three approaches (2010, background): “For example, exposure to a hypoxic environment or vitamin C has been shown to increase the frequency of iPS-cell generatio”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “Furthermore, vitamin C alleviates senescence by reducing but not abolishing p53 and p21 expression levels (Esteban et al., 2010).”
Reprogramming of human primary somatic cells by OCT4 and chemical compounds. (2010, background): “…that can functionally replace exogenous reprogramming TFs and/or enhance the efficiency and kinetics of reprogramming (Shi et al., 2008; Huangfu et al., 2008; Lyssiotis et al., 2009; Ichida et al., 2009; Maherali and Hochedlinger, 2009; Lin et al., 2009; Li et al., 2009; Esteban et al., 2010).”
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. (2010, methodology): “Karyotyping, bisulfate sequencing, semiquantitative RT-PCR for detecting transgene integration, AP staining, teratomas, and injection of iPSCs into chimeric mice were performed like in our previous reports (Esteban et al., 2010).”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “2009) or in the presence of ascorbic acid (Esteban et al. 2010) also seems to target the p53 pathway and thus may provide safer ways to boost iPSC generation.”