Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse.

By M. Stadtfeld, Nimet Maherali, D. Breault, K. Hochedlinger. Cell Stem Cell, 2008

881 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/57a97cad15e08d2c7e6d9854448f98d0f5df9638

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In Molecular Biology

Citations in the corpus

The promise of induced pluripotent stem cells in research and therapy (2012, background): “Markers of pluripotency Fully reprogrammed cells express a network of pluripotency genes, including OCT4 , SOX2 and NANOG , in levels comparable to ES cells, and they reactivate telomerase gene expression, downregulate THY1 and upregulate SSEA1 (ref”
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy (2011, background): “From these observations, and because induced pluripotency is established in a step-wise and stochastic manne”
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. (2012, background): “It has been shown that the endogenous pluripotency markers Sox2 and Nanog are activated after early markers such as alkaline phosphatase (AP) and SSEA1 (Stadtfeld et al., 2008).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, methodology): “Endogenous Nanog and Oct4 activation occur later in the process and are usually associated with a fully reprogrammed state (Brambrink et al., 2008; Stadtfeld et al., 2008a) (Figure 1.11.).”
A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog (2009, background): “Our observation that a one-day treatment with RepSox can relieve the requirement for transgenic Sox2 indicates that unlike reprogramming using transgenic Oct4, Klf4, and Sox2, where each transgene must be expressed for several days (Sridharan et al., 2009; Stadtfeld et al., 2008), small molecules ca”
Epigenetic reprogramming and induced pluripotency (2009, background): “3) (Brambrink et al., 2008; Stadtfeld et al., 2008b).”
Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation (2009, background): “Several studies have reported silencing of the vector-encoded reprogramming factors in iPSCs generated with gamma-retroviral vectors (1, 17, 18).”
Role of the murine reprogramming factors in the induction of pluripotency (2009, neutral): “During the reprogramming process, fibroblast markers are repressed and early embryonic markers like SSEA1 are activated before expression of pluripotency regulators and the self-sustaining pluripotent state are attained (Brambrink et al., 2008; Stadtfeld et al., 2008).”