Epigenetic reprogramming and induced pluripotency

By K. Hochedlinger, Kathrin Plath. Development, 2009

599 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/173fe36fc1fa985b220fd4942753aadcc6cd1ac4

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In Molecular Biology

Citations in the corpus

Molecular maps of the reorganization of genome – nuclear lamina interactions during differentiation (2010, background): “…transcription factors have been identified that keep ESCs in their undifferentiated state, and when artificially introduced in certain combinations they can reprogram differentiated cells back to pluripotent cells, albeit with low efficiency (Hochedlinger and Plath, 2009; Welstead et al., 2008).”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “An additional dramatic example of cellular reprogramming is the ability of ectopic Oct4, Sox2, Klf4, and c-Myc factors to convert somatic cells to pluripotency (Takahashi and Yamanaka 2006; Hochedlinger and Plath 2009).”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “It is unclear how this roadblock is overcome during iPSC derivation, but mechanisms based on either passive or active DNA demethylation have been postulated (Hochedlinger and Plath 2009).”
Polycomb group proteins: navigators of lineage pathways led astray in cancer (2009, unknown): “The idea that the deregulation of CFTFs can change cell fate and lead to tumour development has been highlighted by the recent interest in cellular reprogrammin”
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “Inducing pluripotency Although major inroads have been made into understanding the mechanisms of reprogrammin”
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells (2011, background): “Dedifferentiation of a somatic cell to an induced pluripotent stem cell (iPSC) requires global epigenetic reprogramming and a shift in the expression of thousands of gene”
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells (2010, unknown): “It remains to be tested, however, (1) if other consistent expression changes exist in iPSCs that are not detectable in the undifferentiated state or with current profiling technology; (2) whether iPSC-specific non-recurrent genetic and epigenetic aberrations are present in only some clones; and (3) ”
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy (2011, background): “The key role here for reprogramming factors is probably the induction of a developmentally more naive, open-chromatin state marked by high epigenetic instabilit”