An extended transcriptional network for pluripotency of embryonic stem cells.

By Jonghwan Kim, J. Chu, Xiaohua Shen, Jianlong Wang, Stuart H. Orkin. Cell, 2008

1,431 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6a206efdc49f8bc22750d5857793e46a64a46c36

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

In Molecular Biology

Citations in the corpus

Quantitative and logic modelling of gene and molecular networks (2015, background): “Gene and protein interaction networks have been reconstructed to obtain a comprehensive view of genome regulation 8,25–27 or to understand specific processes (for instance, the regulation of pluripotency) 28–31.”
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008, methodology): “Microarrary Hybridization and Data Processing ChIPed DNA was amplified by ligation-mediated PCR (Kim et al., 2008) and hybridized to Affymetrix mouse tiling 2.0R array sets.”
BET bromodomain inhibition as a therapeutic strategy to target c-Myc (2011, neutral): “Cell 146, no. 6 (September 2011): 904–917.”
Genome-wide characterization of transcriptional start sites in humans by integrative transcriptome analysis. (2011, result): “been discussed in previous reports (Heintzman et al. 2007; Kim et al. 2008); however, this is the first study to provide direct evidence”
Nanog Is the Gateway to the Pluripotent Ground State (2009, neutral): “This restricted expression of Nanog is associated with and essential for prosecuting the transition to pluripotency in a subset of cells that already express Oct4 and Sox2.”
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency (2011, positive): “Hdac2 has also been found to be part of an extended regulatory network for pluripotency in ESCs by interacting with both Oct4 and Myc (Kim et al., 2008).”
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (2010, background): “In ES cells, c-Myc occupies genes involved in cellular proliferation, as it does in other cell types (Chen et al., 2008; Kidder et al., 2008; Kim et al., 2008).”
Facilitators and Impediments of the Pluripotency Reprogramming Factors’ Initial Engagement with the Genome (2012, neutral): “In contrast, c-Myc binds almost exclusively to promoters in ES cells (Figure 2C) (Chen et al., 2008; Kim et al., 2008; Sridharan et al., 2009).”
Myc's broad reach. (2008, background): “Similar histone methylation determinants of Myc binding have also been shown in a genome-wide binding study of embryonic stem (ES) cells (Kim et al. 2008).”
Role of the murine reprogramming factors in the induction of pluripotency (2009, neutral): “Consistent with published observations (Chen et al., 2008; Kim et al., 2008), genes occupied by only c-Myc are activated more strongly than those bound singly by Oct4, Sox2, or Klf4.”
Epigenetic reprogramming and induced pluripotency (2009, background): “…Liver cells ND Fbx15 Aoi et al., 2008 Intestinal epithelium* ND Nanog Wernig et al., 2008 β cells 0.1-0.2% Morphology Stadtfeld et al., 2008 Ectoderm Neural progenitors <3.6% Oct4 Kim et al., 2008; Shi et al., 2008; Eminli et al., 2008 Keratinocytes* ND Nanog Wernig et al., 2008 *Secondary cells.”
Fast Batch Alignment of Single Cell Transcriptomes Unifies Multiple Mouse Cell Atlases into an Integrated Landscape (2018, background): “All members of the pluripotency core network ( Nanog , Pou5f1 , Sall4 , Esrrb , Lin28a ) 39 form a cohesive cluster, and the cell type annotation accurately describes them as embryo-speciﬁc.”
Control of Embryonic Stem Cell State (2011, background): “It is therefore likely that functional enhanceosomes are formed at most MTL.”