Generation of germline-competent induced pluripotent stem cells

By K. Okita, T. Ichisaka, S. Yamanaka. Nature, 2007

4,380 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f72901d4b1f7237027250a20eb27fc260aa78156

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Citations in the corpus

Mechanisms of stem cell self-renewal. (2009, background): “…combinations of other transcription factors including Sox2 and Nanog can reprogram differentiated mouse and human cells into ES-like induced pluripotent stem (iPS) cells (Okita et al. 2007, Park et al. 2008, Takahashi et al. 2007, Takahashi & Yamanaka 2006, Wernig et al. 2007, Yu et al. 2007).”
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. (2008, neutral): “Inducible Expression of Reprogramming Factors in the B Cell Lineage Our initial strategy was to determine whether Oct4, Sox2, Klf4 and c-Myc transcription factors, which were shown to be sufficient to reprogram mouse and human fibroblast cultures (Meissner et al., 2007; Okita et al., 2007; Takahashi”
A fresh look at iPS cells. (2009, background): “(Meissner et al., 2007; Okita et al., 2007; Wernig et al., 2007); similar reporter systems may be needed for human cells.”
A combined chemical and genetic approach for the generation of induced pluripotent stem cells. (2008, neutral): “…into induced pluripotent stem (iPS) cells have opened up tremendous opportunities for the stem cell field (Maherali et al., 2007; Meissner et al., 2007; Nakagawa et al., 2008; Okita et al., 2007; Takahashi et al., 2007; Takahashi and Yamanaka, 2006; Wernig et al., 2007, 2008; Yu et al., 2007).”
MLL translocations, histone modifications and leukaemia stem-cell development (2007, background): “Although reprogrammed fibroblasts share more features with ES cells than LSCs that originate from GMPs, it may be that the generation of LSCs from progenitors represents a type of partial or failed reprogrammin”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “However it was later proven by Yamanaka’s group, as well as by others, that iPS cells capable of germline transmission could be generated (Maherali et al., 2007; Meissner et al., 2007; Okita et al., 2007; Wernig et al., 2007).”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “…achieved a breakthrough in this field by demonstrating that the overexpression of four transcription factors, Oct4, Sox2, Klf4, and c-Myc, can convert somatic fibroblasts to pluripotent cells (iPSCs) that can contribute to the germline in chimeric mice (Okita et al., 2007; Wernig et al., 2007).”