Role of Microglia in Neurotrauma
By David J. Loane, Kimberly R. Byrnes. Neurotherapeutics, 2010
645 citations recorded by the source corpus.
SummaryMicroglia are the primary mediators of the immune defense system of the CNS and are integral to the subsequent inflammatory response. The role of microglia in the injured CNS is under scrutiny, as research has begun to fully explore how postinjury inflammation contributes to secondary damage and recovery of function. Whether microglia are good or bad is under debate, with strong support for a dual role or differential activation of microglia. Microglia release a number of factors that modulate secondary injury and recovery after injury, including pro- and anti-inflammatory cytokines, chemokines, nitric oxide, prostaglandins, growth factors, and Superoxide species. Here we review experimental work on the complex and varied responses of microglia in terms of both detrimental and beneficial effects. Addressed in addition are the effects of microglial activation in two examples of CNS injury: spinal cord and traumatic brain injury. Microglial activation is integral to the response of CNS tissue to injury. In that light, future research is needed to focus on clarifying the signals and mechanisms by which microglia can be guided to promote optimal functional recovery.
Subfields: Neurology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/a82f6b761c8aeaaa234eb871a90cda30e7153cd8
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Neurology
In Pathology and Forensic Medicine
Citations in the corpus
- Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. (2012, positive): “In addition to the infiltration of immune cells, the activation of resident microglia play a major role in the response to brain injury (Loane and Byrnes, 2010).”