Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

By Jason Netland, D. Meyerholz, Steven Moore, M. Cassell, S. Perlman. Journal of Virology, 2008

1,135 citations recorded by the source corpus.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/60cdd947e4aae2fb97e461cc897a3212e253ce8b

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Citations in the corpus

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (2019, background): “After an intranasal infection, both HCoV-OC43 and SARS-CoV were shown to infect the respiratory tract in mice and to be neuroinvasive [261] [262] [263] [264] [265] .”
Coronaviruses post-SARS: Update on replication and pathogenesis (2009, background): “Although these mice develop more severe pulmonary disease than non-transgenic mice, they also develop an overwhelming neuronal infection, accompanied by high cytokine and/or chemokine expression and minimal cellular infiltration in the brai”
Coronavirus Pathogenesis (2011, background): “In both of these models, the transgenic mice rapidly succumb after intranasal inoculation of SARSCoV due to infection of the CNS, limiting their usefulness in the pathogenesis of SARS (Netland et al., 2008; Tseng et al., 2007).”
Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development (2020, background): “Previous studies have reported that coronaviruses, such as SARS-CoV-1, and mouse hepatitis viruses could enter the central nervous system following intranasal inoculation of mice (25, 26).”
Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors (2020, positive): “Notwithstanding possible brain infiltration, “cytokines storm” involved in the immune response to coronaviruses may cause psychiatric symptoms by precipitating neuroinflammation (Dantzer, 2018; Netland et al., 2008).”
SARS-like WIV1-CoV poised for human emergence (2016, methodology): “Based on pilot studies and previous studies with ACE2 transgenic animals (12), mice experiencing rapid weight loss were predicted to have lethal encephalitis and were humanely killed and harvested for lung and brain titer if weight loss approached >20% of starting body weight.”
Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study (2020, background): “SARS-CoV has demonstrated in a mice model a transneural penetration through the olfactory bulb [6].”
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis (2020, neutral): “For example, both SARS-CoV and SARS-CoV-2 infections lead to encephalitis in these mouse models, which is not common in patients with COVID-19 [115,117,118].”
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study (2020, background): “Thus, for the SARS-CoV receptor (human angiotensin-converting enzyme 2), it has been demonstrated on transgenic mice that SARS-CoV may enter the brain through the olfactory bulb, leading to rapid transneuronal spread [14] .”
Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms (2020, background): “3 The presence of the COVID-19 virus in the general circulation understandably enables it to pass into the cerebral circulation ( Figure 1A−C) where the sluggish movement of the blood within the microcirculation could be one of the factors that may facilitate the interaction of the COVID-19 virus sp”