Microglia as a source and target of cytokines

By U. Hanisch. Glia, 2002

1,618 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/f5e2d31821e1bb770166e9a3b436f79c19729e98

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Michael T. Heneka
2. M. O’Banion
3. J. Lladó
4. G. Olmos
5. G. Moalem-Taylor
6. P. Austin
7. Marco Prinz
8. R. Ji

In Neurology

1. R. Ji
2. Clifford J. Woolf
3. G. Moalem-Taylor
4. P. Austin
5. M. Suter
6. Michael T. Heneka
7. M. O’Banion
8. J. Lladó

Citations in the corpus

• Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. (2005, background): “…that the inability of macrophages to clear insoluble material results in a phenomenon described as ''frustrated phagocytosis,'' which is characterized by increased secretion of inflammatory products that may directly or indirectly cause neuronal death or alter synaptic activity (Hanisch, 2002).”
• Glia and pain: Is chronic pain a gliopathy? (2013, background): “Interestingly, even acute opioid treatment after a subcutaneous injection results in marked SGC reaction in DRGs at 2 hours when morphine analgesia declines [18] (Table 1).”
• p38 MAPK, microglial signaling, and neuropathic pain (2007, background): “Microglia are regarded as a main source of IFMs in the CNS [12,13].”
• Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions (2007, background): “These cells share many phenotypical and functional characteristics with other tissue macrophages and with peripheral blood monocytes, suggesting that microglia participate in many immune reactions of the brai”
• p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain (2003, background): “Microglia are a source of multiple cytokines, including interleukin-1 (IL-1), IL-6, and tumor necrosis factor- ( Hanisch, 2002 ).”
• Role of Microglia in Central Nervous System Infections (2004, background): “A major contribution of the recent renaissance of research on microglia has been an understanding of the critical role of cytokine/chemokine receptors (Table 1) and their cognate ligands (Table 2) in directing the migration and the activation of microglial cells, topics that have been reviewed elsew”
• Inflammatory processes in Alzheimer's disease. (2007, positive): “IL-1, IL-6, TNF-αMIP-1α and MCP-1 increase in a dose-dependent manner after cultured microglia are incubated with Aβ (Floden and Combs, 2006; Lindberg et al., 2005; Benveniste et al., 2001; Butovsky et al., 2005; Veerhuis et al., 2005; Hanisch, 2002; Lue et al., 2001b; Lee et al., 2002).”