Adipocytes as regulators of energy balance and glucose homeostasis

By E. Rosen, B. Spiegelman. Nature, 2006

2,152 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/caad0a86d9a5e9fcf50711440c02944af9f55fb5

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In Endocrine and Autonomic Systems

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Citations in the corpus

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes (2008, background): “Adipocytes have a particularly large capacity to synthesize and store triglycerides during feeding, as well as to hydrolyse and release triglycerides as FFAs and glycerol during fastin”
Chemerin is a novel adipokine associated with obesity and metabolic syndrome. (2007, background): “These macrophages secrete other proinflammatory cytokines such as TNF- and IL-6, which can act in a paracrine fashion to affect insulin sensitivity of adipocytes or as endocrine factors to affect insulin sensitivity of distal tissues, such as skeletal muscle and liver (5).”
Activated Type 2 Innate Lymphoid Cells regulate Beige Fat Biogenesis (2014, positive): “White adipose tissue (WAT) is a highly dynamic organ that responds to nutrient and environmental stress (Berry et al., 2014; Rosen and Spiegelman, 2006; Rosen and Spiegelman, 2014; Zeve et al., 2009).”
Adipocytokines in Obesity and Metabolic Disease (2014, positive): “Therefore, like other well-studied adipocytokines, it is conceivable that secreted aP2 could potentially act on other key organs such as the CNS or heart to regulate other aspects of metabolic homeostasis (Fig.”
Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules (2016, background): “As such, the adipose tissue is considered an important energy store in healthy humans and serves as an essential regulator of energy balance and glucose homeostasis [2].”
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis (2009, background): “It integrates metabolic signals and in turn regulates systemic energy balance by secreting adipokines, including leptin, adiponectin, and tumor necrosis factor (TNF)- (1, 3).”
Inflammatory Mechanisms in the Regulation of Insulin Resistance (2008, background): “Besides the fact that IR is characterized by complex interactions between genetic determinants, nutritional factors, and lifestyle, it is increasingly recognized that mediators synthesized from cells of the immune system as well as by adipose tissue are critically involved in the regulation of insul”
Identification of white adipocyte progenitor cells in vivo. (2008, background): “Obesity, the excessive accumulation of white adipose tissue (WAT), is a highly prevalent condition that results from an imbalance of energy expenditure versus food intake, leading to an increase in the storage of energy in the form of lipid within WAT (Rosen and Spiegelman, 2006).”
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling (2011, background): “WAT functions as an energy storage depot characterized by large lipid droplets and is a prominent endocrine organ, producing hormones that regulate feeding and satiety (Rosen and Spiegelman, 2006).”